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Tau in neurodegenerative diseases: Tau phosphorylation and assembly |
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| Authors: | |
| Institution: | (1) Department of Neurology, Medical College Hospital, Thiruvananthapuram, 695011, Kerala, India;(2) Department of Biochemistry, Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST), Thiruvananthapuram, 695011, Kerala, India;(3) Cognition and Behavioural Neurology Section (CBNC), Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST), Thiruvananthapuram, 695011, Kerala, India |
| Abstract: | The possible link between tau phosphorylation and tau assembly in these neurodegenerative diseases known as tauopathies is described. Additionally, this link is supported by an in vitro experiment showing the higher capacity of phosphotau to assemble in some specific conditions; and, by a recently reported experiment using a tau transgenic mouse model. |
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