帕罗西汀治疗咽异感症患者抑郁、焦虑症状的临床观察

目的 探讨帕罗西汀对咽异感症的疗效及安全性.方法 选自门诊咽异感症病人共66例,随机分为帕罗西汀组(33例)和丁螺环酮组(33例),疗程6周.采用汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)评定临床疗效,副反应量表(TESS)评定副反应.结果 帕罗西汀组治疗前后的HAMD及HAMA评分比较有显著性差异(P＜0.01),两组问从治疗第2周末起,各时点HAMD评分有显著性差异(P＜0.05);两组问HAMA评分在治疗第2周末有显著性差异(P＜0.05);在第4、6周末无显著性差异(P＞0.05);两组间备时点TESS评分显著性差异(P＞0.05).结论 帕罗西汀在显著改善咽异感症患者抑郁症状的同时,其改善焦虑症状的疗效与抗焦虑药物丁螺环酮相当,疗效较好,副作用小.

Clinical Observation of Paroxetine in the Treatment of Patients with Pharyngeal Paraesthesia in Depression and Anxiety

Objective To investigate the effect and safety of paroxetine in patients with pharyngeal paraesthesia.Methods 66 cases of outpatients with pharyngeal paraesthesia were randomly divided into paroxetine group(33 cases) and buspirone group(33 cases) HAMD and HAMA were used to evaluated the clinical effect.Tess was used to evaluated the side-effect.The two groups were observed about 6 weeks.Results The evaluation of HAMD and HAMD in paroxetine group showed a significant difference between before and after therapy(P<0.01).The evaluation of HAMD between the two groups showed a significant difference at different time from the second weekend(P<0.05).The evaluation of HAMA between the two groups showed a significant difference on the second weekend(P<0.05),but showed no significant of tess between two groups showed no significant difference at different time(P<0.05).Conclusion Paroxetine can significantly improve the depress in patients with pharyngeal paraesthesia.Meanwhile it is equal to buspirone in patients with anxiety.Paroxtine shows a significant effect with less side-effect in patient of pharyngeal paraesthesia with depress and anxiety.