上皮膜抗原免疫细胞化学检查在脑膜癌病中的诊断价值

目的　探讨上皮膜抗原(EMA)免疫细胞化学检查方法在诊断脑膜癌病(MC)中的价值。方法 　采用常规脑脊液(CSF)细胞学和EMA免疫细胞化学方法检查14例确诊为MC患者的CSF标本,共23份。 结果　常规CSF细胞学检查发现肿瘤细胞的阳性率为39.13%(9/23),EMA免疫细胞化学检查的阳性率为 86.96%(20/23),两者比较差异有极显著性(P<0.01);其中对首次腰穿获得的CSF标本检查,两种方法的阳 性率分别为28.57%(4/14)和78.57%(11/14),两者比较差异也有显著性(P<0.05)。结论　EMA免疫细胞 化学检查方法诊断MC的敏感性优于常规CSF细胞学检查。

Diagnosis value of epithelial membrane antigen immunocytochemistry examination in meningeal carcinomatosis

Objective To assess the diagnosis value of epithelial membrane antigen (EMA) immunocytochemistry examination in meningeal carcinomatosis.Methods The routine cerebrospinal fluid cytologic examination and EMA immunocytochemistry examination of 23 cerebrospinal fluid specimens from 14 patients with definitive meningeal carcinomatosis were analyzed,retrospectively.Results The positive rate of routine cerebrospinal fluid cytologic examination and EMA immunocytochemistry examination were 39.13%(9/23)and 86.96%(20/23),respectively. There was a significant difference between two results ( P<0.01). The two positive rates were 28.57% (4/14) and 78.57%(11/14)in the first cerebrospinal fluid specimens,there was also a significant difference between the results ( P<0.05). Conclusion The sensitivity of EMA immunocytochemistry examination is superior to routine cerebrospinal fluid cytologic examination in the diagnosis of meningeal carcinomatosis.