| 实验性抑郁症大鼠缰核和海马BDNF基因表达 |
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| 引用本文： | 夏薇,赵华,任爱华,沈维高. 实验性抑郁症大鼠缰核和海马BDNF基因表达[J]. 中国免疫学杂志, 2005, 21(4): 277-278 |
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| 作者姓名： | 夏薇 赵华 任爱华 沈维高 |
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| 作者单位： | 吉林大学基础医学院生理教研室,长春,130021 |
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| 摘 要： | 目的：研究抑郁症大鼠缰核和海马BDNF基因的表达情况。方法：采用长期未预知应激刺激致大鼠抑郁症模型，运用open-field和forced swinmming test法观察大鼠行为学变化。运用免疫组化法检测缰核和海马BDNT基因的表达。结果：与正常对照组相比，抑郁症模型组大鼠海马和缰核均表现为BDNF阳性细胞数量明显减少。结论：实验性抑郁症大鼠缰核、海马BDNF基因表达水平降低。
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| 关 键 词： | 抑郁症 缰核 海马 BDNF基因 |
| 文章编号： | 1000-484X(2005)04-0277-02 |
Changes of BDNF level expression in Hippocampal and Habenular nucles in experimental depression rats |
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| XIA Wei,ZHAO Hua,REN Ai-Hua,SHEN Wei-Gao. Changes of BDNF level expression in Hippocampal and Habenular nucles in experimental depression rats[J]. Chinese Journal of Immunology, 2005, 21(4): 277-278 |
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| Authors: | XIA Wei ZHAO Hua REN Ai-Hua SHEN Wei-Gao |
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| Affiliation: | XIA Wei,ZHAO Hua,REN Ai-Hua,SHEN Wei-Gao.Department of Physiology,School of Basic Medical Sciences,Jilin University,Changchun 130021,China |
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| Abstract: | Objective:To observe the change of BDNF level expression in experimental in hippocampal and habenular nucles in experimental depression rats.Methods:The depression model of rats was established by chronic unpredictable mild stress. Openfield test was performed to detect the behavior of rats. Immunohistochemistry was used to observe the changes of BDNF level.Results:Compared to the control group,the number of depressed animals was much less than that of normal animals.Conclusion:The level of BDNF decrease significantly in experimental depressive model of rats. |
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| Keywords: | Depression Hippocampal Habenular nucles(Hb) Brain-derived neurotrophic factor BDNF |
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