骨质疏松症中医证型与细胞因子、性激素、骨钙素的相关性临床研究

目的：探讨骨质疏松症中医证型与细胞因子、性激素、骨钙素的相关性。方法：两个医院在3个月内收集80例骨质疏松症患者，辨证分为肾阳虚衰、肝肾阴虚、脾肾阳虚、气滞血瘀四组，抽取血液样本，检测七个指标：雌二醇（E2）、睾酮（T）、白介素-6（IL-6）、肿瘤坏死因子（TNF—α）、胰岛素样生长因子（IGF-1）、骨保护素（OPG）、骨钙素（BGP）。结果：E2在四组证型的气滞血瘀组与肾阳虚衰组之间有统计学意义（P=0．008），IGF-1z在四组证型的肝肾阴虚组与气滞血瘀组之间有统计学意义（P=0．035），余指标的四组证型未见有统计学意义。结论：雌二醇（E2）／胰岛素样生长因子（IGF-1）两个指标可以作为骨质疏松症中医证型虚证（肾阳虚衰或肝肾阴虚）与实证（气滞血瘀）的鉴别诊断指标之一，中医证型存在客观的现代医学指标。

Clinical Study of the Relationships Between Four TCM Syndrome And Cytokines/Hormones/BGP

Objective： To explore the Relationships Between Four TCM Syndromes And Cytokines/Hormones/BGP in Osteoporosis. Methods： Eighty cases were seperated into four groups according four TCM syndromes. The first TCM syndrome was spleen yan--deficiency,The second one was spleen and kidney yan--deficency,The third one was liver and kidney yin- defieeney,The fourth one was qi-blood stasis. Estradiol（E2）/ Testosterone（T）/IL-6/IGF-1/TNF-α /OPG and BGP were examined in the blood plasma In every case. Results： There was distinguishable difference between qi-blood stasis and kidney yan-deficiency in E2 （P= 0.008） ; There was distinguishable difference between qi-blood stasis and liver and kidney yin-deficiency in IGF-1（P= 0. 035）, There was no distinguishable difference between other groups in T/IL--6/ TNF/OPG and BGP. Conclusion： E2/IGF- 1 can be treated as one of indexs of differentiation diagnosis between excess and deficiency, There are objective basis in differentiation of TCM syndrome.