| 阿扎司特滴眼液对家兔眼刺激性试验 |
| |
| 引用本文： | 张强,周玲,胡志力.阿扎司特滴眼液对家兔眼刺激性试验[J].齐鲁药事,2005,24(2):116-117. |
| |
| 作者姓名： | 张强 周玲 胡志力 |
| |
| 作者单位： | 山东省医科院药物所,济南,250062 |
| |
| 摘 要： | 目的 观察阿扎司特滴眼液对兔眼刺激性影响。方法 计数兔眨眼次数、短期多次给药眼刺激 (1次 / 15min ,连续滴眼 2h)和长期给药眼刺激 (5次·d-1,连续滴眼 4w)作用。结果 阿扎司特滴眼液对兔眨眼次数与赋形剂对照液比较无明显差异 (P >0 0 5 )。短期多次及长期给药刺激试验对兔眼均无明显影响 ,双眼角膜透明 ,无混浊 ,虹膜纹理清晰 ,结膜无充血 ,无水肿、无分泌物。结论 阿扎司特滴眼液临床应用是安全的
|
| 关 键 词： | 阿扎司特滴眼液 家兔 刺激性 |
| 文章编号： | 1672-7738(2005)02-0116-02 |
Irritant test of Acitazanolast Eye Drops on rabbit eyes |
| |
| Zhang Qiang,Zhou Ling,HU Zhi-li.Irritant test of Acitazanolast Eye Drops on rabbit eyes[J].qilu pharmaceutical affairs,2005,24(2):116-117. |
| |
| Authors: | Zhang Qiang Zhou Ling HU Zhi-li |
| |
| Abstract: | Objective To test the irritant effect of Acitazanolast Eye Drops on rabbit eyes.Methods The rabbit nictitation counting,short-time multiple eye drops irritation (once per 15 minute for continuously 2 hours) and long-time eye drops irritation (5 times per day for continuously 4 weeks) were observed.Results There was no significant difference on rabbit nictitation between Acitazanolast Eye Drops and excipient control (P>0.05).Furthermore,short-time multiple and long-time regular irritation had no markedly influences on tested rabbit eyes,with cornea being transparent without turbidness and iris clarity,no conjunctiva hyperemia,edema and secreta.Conclusion Acitazanolast Eye Drops is safe for clinical application. |
| |
| Keywords: | Acitazanolast rabbit irritant |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
