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Diagnostics of paraneoplastic neurological syndromes
Authors:Marco Zoccarato  Matteo Gastaldi  Luigi Zuliani  Tiziana Biagioli  Marco Brogi  Gaetano Bernardi  Elena Corsini  Elena Bazzigaluppi  Raffaella Fazio  Claudia Giannotta  Eduardo Nobile-Orazio  Gianna Costa  Raffaele Iorio  Amelia Evoli  Sara Mariotto  Sergio Ferrari  Elisabetta Galloni  Valentina De Riva  Elisabetta Zardini  Diego Franciotta  Bruno Giometto
Affiliation:1.Ospedale S. Antonio AULSS Euganea,Padua,Italy;2.C. Mondino National Neurological Institute,University of Pavia,Pavia,Italy;3.Ospedale Ca’ Foncello AULSS2 Marca Trevigiana,Treviso,Italy;4.AOU Careggi,Florence,Italy;5.C. Besta Neurological Institute,Milan,Italy;6.Ospedale San Raffaele,Milan,Italy;7.Humanitas Clinical Institute,Milan University,Milan,Italy;8.Ospedale R. Binaghi,Cagliari,Italy;9.Policlinico A. Gemelli,Università Cattolica del Sacro Cuore,Rome,Italy;10.Department of Neuroscience, Biomedicine and Movement,University of Verona,Verona,Italy;11.Ospedale S. Bortolo,Vicenza,Italy;12.C. Mondino National Neurological Institute,Pavia,Italy;13.UO Neurologia, Ospedale S.Antonio, AULSS 6 Euganea,Padova,Italy
Abstract:This document presents the guidelines for onconeural antibody testing that have been developed following a consensus process built on questionnaire-based surveys, internet contacts, and discussions at workshops of the sponsoring Italian Association of Neuroimmunology (AINI) congresses. Essential clinical information on paraneoplastic neurological syndromes, indications and limits of onconeural antibody testing, instructions for result interpretation, and an agreed laboratory protocol (Appendix) are reported for the communicative community of neurologists and clinical pathologists.
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