Extracellular matrix and lung inflammation |
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Authors: | Jesse Roman MD |
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Institution: | 1. Department of Medicine, Division of Pulmonary and Critical Care Medicine, Atlanta Veterans Affairs Medical Center, Emory University School of Medicine, Atlanta, Ga., USA 2. Department of Medicine Pulmonary and Critical Care Medicine Section Atlanta VA, Medical Center, 1670 Clairmont Road, 30033, Decatur, GA, (USA)
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Abstract: | Lung injury triggers an acute inflammatory response characterized by increased expression and deposition of extracellular matrix (ECM) components such as fibronectin and collagen. Although the function of newly deposited matrices in injured lungs is unknown, their ability to affect the migration, proliferation, differentiation, and activation state of cells in vitro suggests an important role in the initiation and maintenance of the inflammatory response in vivo. Interactions between immune and nonimmune cells with the lung ECM are mediated via cell surface receptors of the integrin family which link the ECM with intracellular molecules involved in signal transduction. Activation of integrin-mediated intracellular signals may promote inflammation by facilitating leukocyte recruitment and cytokine expression. *** DIRECT SUPPORT *** A02GS030 00009 |
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