| In vitro toxicologic study of chitin short fiber reinforced polycaprolactone composite |
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| 作者姓名： | 段亮 徐志飞 秦雄 孙康 赵学维 方嘉 龚志云 |
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| 作者单位： | [1]DepartmentofCardiothoraeicSurgery,ChangzhengHospital,SecondMilitaryMedicalUniversity,Shanghai200003,China [2]InstituteofCompositeMaterials,ShanghaiJiaotongUniversity,Shanghai200030,China |
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| 基金项目： | Supported by the Sci & Tech Development Foundation of Shang-hai (No. 024419076) |
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| 摘 要： | To investigate the cytotoxicity and cytocompatibility of chitin fiber reinforced polycaprolactone composite in vitro in order to provide useful scientific basis for clinical application. Methods: Cell morphology, observation,MTF and DNA assay were used to evaluate the influence of the composite on the morphology, growth and proliferation of cultured L-929 cells. Results: The composite did not impair the morphology of cultured cells in vitro. MTF and DNA assay demonstrated that the growth and proliferation of the cultured cells were not significantly inhibited by the composite. Conclusion: The composites have fine cytocompatibility and are safe for clinical use of reconstruction of chest wall defects.
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| 关 键 词： | 毒理学 甲壳质 光纤 复合聚已酸内酯 细胞分化 细胞毒性 |
In vitro toxicologic study of chitin short fiber reinforced polycaprolactone composite |
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| DUAN Liang,XU Zhi-fei,QIN Xiong,SUN Kang,ZHAO Xue-wei FANG Jia,GONG Zhi-yun.In vitro toxicologic study of chitin short fiber reinforced polycaprolactone composite[J].Journal of Medical Colleges of PLA(China),2004,19(6):353-356. |
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| Authors: | DUAN Liang XU Zhi-fei QIN Xiong SUN Kang ZHAO Xue-wei FANG Jia GONG Zhi-yun |
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| Institution: | DUAN Liang,XU Zhi-fei,QIN Xiong,SUN Kang,ZHAO Xue-wei FANG Jia,GONG Zhi-yun Department of Cardiothoracic Surgery,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China Institute of Composite Materials,Shanghai Jiaotong University,Shanghai 200030,China |
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| Abstract: | Objective: To investigate the cytotoxicity and cytocompatibility of chitin fiber reinforced polycaprolactone composite in vitro in order to provide useful scientific basis for clinical application. Methods: Cell morphology observation, MTT and DNA assay were used to evaluate the influence of the composite on the morphology, growth and proliferation of cultured L-929 cells. Results: The composite did not impair the morphology of cultured cells in vitro. MTT and DNA assay demonstrated that the growth and proliferation of the cultured cells were not significantly inhibited by the composite. Conclusion : The composites have fine cytocompatibility and are safe for clinical use of reconstruction of chest wall defects. |
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| Keywords: | chitin fiber reinforce polycaprolactone cytotoxicity cytocompatibility |
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