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目的探讨儿童急性白血病SODD和P65蛋白的表达及其临床意义。方法2004年3～11月采用免疫组化SABC法,检测华中科技大学同济医学院附属同济医院儿科住院急性白血病(AL)患儿骨髓涂片中SODD、P65蛋白表达。结果33例AL中,SODD和P65表达阳性率分别为54.5%(18/33)和45.5%(15/33),与正常对照组相比差异有显著性(P<0.05);25例急性淋巴细胞白血病(ALL)中,SODD和P65表达的阳性率分别为56.0%(14/25)和48.0%(12/25),与正常对照组相比差异有显著性(P<0.05)。ALL高危病例组中SODD阳性表达率为75.0%(12/16),较标危病例组阳性率高,差异有显著性(P<0.05)。33例AL患儿中SODD和P65均为阳性12例,均阴性16例,表达一致符合率为84.8%(28/33),两者的表达呈正相关(P<0.01,r=0.69)。结论SODD和P65均参与了AL的发生发展;SODD过表达与儿童ALL的发生、临床分型以及预后均有密切关系。

Expression of SODD and P65 protein in pediatric acute leukemia and clinical significance

Objective To study the expression of SODD and P65 in pediatric acute leukemia and its clinical significance.Methods The expression of SODD and P65 proteins were determined by immunohistochemistry method.Results The incidence of SODD and P65 expression was 54.5%(18/33) and 45.5%(15/33)in acute leukemia (AL)( P <0.05 ),in ALL the incidence of SODD and P65 expression was 56%(14/25) and 48%(12/25)respectively( P <0.05 ).The positive incidence of SODD was 93.3%(14/15) in 15 cases with P65 expression and the positive incidence of P65 was 77.8%(14/18) in 18 cases with SODD expression,which had a positive correlation between SODD expression and P65 expression( P <0.01, r =0.69 ).A significant correlation was found between SODD and the immunity grouping and the judgement of prognosis( P <0.05 ).Conclusion The overexpression of SODD and P65 may promote to tumorgenesis and progression in AL.The SODD can act as markers of predicting biological behaviors and prognosis in ALL.