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Increased systemic microvascular albumin flux in septic shock |
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| Authors: | A B J Groeneveld G J J Teule W Bronsveld G C van den Bos L G Thijs |
| Institution: | (1) Medical Intensive Care Unit, Free University Hospital, Amsterdam, The Netherlands;(2) Department of Nuclear Medicine, Free University Hospital, Amsterdam, The Netherlands;(3) Department of Physiology, Free University Hospital, Amsterdam, The Netherlands;(4) Medical Intensive Care Unit Department of Internal Medicine Academisch Ziekenhuis, Vrije Universiteit, De Boelelaan 1117, NL-1081 HV Amsterdam, The Netherlands |
| Abstract: | Lymph/plasma (L/P) albumin ratios were followed in a patient with a traumatic thoracic duct lymph fistula, during septic shock when lymph flow was high and at recovery when lymph flow was low. Higher albumin ratios were found during the former. On both occassions, the P-L difference of radioactive counts/min per gram was followed for 6 h after i.v. injection of 51Cr human serum albumin (HSA). Equilibration half times between plasma and lymph amounted to 0.85 h during septic shock and 2.49 h at recovery. The data indicate that systemic microvascular albumin flux had increased during shock in our patient. Increased permeability may have been responsible. |
| Keywords: | Septic shock Capillary permeability Adult respiratory distress syndrome Lymph fistula |
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