| Synthesis,characterization, and anti-cancer activity of emodin-Mn（Ⅱ） metal complex |
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| 作者姓名： | YANG Li, TAN Jun, WANG Bo-Chu, ZHU Lian-Cai |
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| 作者单位： | [1]Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, College of Bioengi-neering, Chongqing University, Chongqing 400030, China; [2]School of Biological & Chemical Engineering, Chongqing University of Education, Chongqing 400067, China |
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| 基金项目： | This project was supported by the Natural Science Foundation Project of CQ CSTC （No. 2011BB5109）, Program for Innovation Team Building at Institutions of Higher Education in Chongqing （KJTD201325）, and Visiting Scholar Foundation of Key Laboratory of Biorheological Science and Technology （Chongqing University）, Ministry of Education （CQKLBST-2012- 007）, and the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry. |
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| 摘 要： | To synthesize and characterize a novel metal complex of Mn （Ⅱ） with emodin, and evaluate its anti-cancer activity. The elemental analyses, IR, UV-vis, atomic absorption spectroscopy, TG-DSC, ^1H NMR, and ^13C NMR data were used to characterize the structure of the complex. The cytotoxicity of the complex against the human cancer cell lines HepG2, HeLa, MCF-7, B16, and MDA-MB-231 was tested by the MTT assay and flow cytometry. Emodin was coordinated with Mn（Ⅱ） through the 9-C=O and 1-OH, and the general formula of the complex was Mn（Ⅱ） （emodin）2.2H/O. In studies of the cytotoxicity, the complex exhibited significant activity, and the IC50 values of the complex against five cancer cell lines improved approximately three-fold compared with those of emodin. The complex could induce cell morphological changes, decrease the percentage of viability, and induce G0/G1 phase arrest and apoptosis in cancer cells. The coordination of emodin with Mn（Ⅱ） can improve its anticancer activity, and the complex Mn（Ⅱ） （emodin）2.2H2O could be studied further as a promising anticancer drug.
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| 关 键 词： | Emodin Cytotoxicity Metal complex Cell cycle arrest Apoptosis |
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