| CORRELATIONS AMONG EXPRESSION OF ANGIOPOIETIN-1 TO CLINICAL PATHOLOGICAL CHARACTERISTICS AN ANGIOGENESIS IN ORAL SQUAMOUS CELL CARCINOMA |
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| 引用本文： | 李超,陈建超,王朝晖,张兵,李彬,宋宇峰. CORRELATIONS AMONG EXPRESSION OF ANGIOPOIETIN-1 TO CLINICAL PATHOLOGICAL CHARACTERISTICS AN ANGIOGENESIS IN ORAL SQUAMOUS CELL CARCINOMA[J]. 中国癌症研究, 2006, 18(3): 198-202. DOI: 10.1007/s11670-006-0198-3 |
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| 作者姓名： | 李超 陈建超 王朝晖 张兵 李彬 宋宇峰 |
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| 作者单位： | [1]Department of Head and Neck Surgery, Sichuan Cancer Hospital, Chengdu 610041 [2]Department of Oral and Maxillary Surgery, The Affiliated Hospital,Guiyang Medical College, Guiyang 550004 |
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| 基金项目： | This work was supported by the Medical Science Grant of Sichuan Province Key Sci ＆ Tech Subjects （No. 20020807） and Guizhou Province Government Century Grant （No.9813）. |
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| 摘 要： | Objective： To study the expression and the significance of Angiopoietin-1 （Ang-1） through observing the correlations among the expression of Ang-1 to clinicopathologic characteristics and microvessel density （MVD） in oral squamous cell carcinoma （OSCC）. Methods： Expressions of Angiopoietin-1 and CD34 in 41 human OSCC tissues, 30 adjacent noncancerous oral tissues and 10 normal oral mucosas were detected by immunohistochemical SABC method. MCD was also assessed. Results： Of the 41 OSCC tissues, 41.46% （17/41） was Ang-1 positive. The expression of Ang-1 was significantly lower in OSCC than that in adjacent noncancerous oral tissues （P〈0.05） and normal oral mucosa （P〈0.05）. The Ang-1 expression was significantly higher in high differentiated tumor than that in moderately differentiated tumor （P〈0.05）. The MVD was significantly higher in Ang-1-negative OSCC than in Ang-1-positive OSCC （P〈0.01）, and negatively correlated with the expression of Ang-1 （r=-0.32, P〈0.05）. Conclusion： Down-regulated expression of Ang-1 may play a crucial role in the development of OSCC. It negatively regulated the angiogenesis of tumor.
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| 关 键 词： | 临床病理学 血管生成 鳞状细胞癌 临床治疗 |
| 文章编号： | 1000-9604（2006）03-0198-05 |
| 收稿时间： | 2006-03-06 |
| 修稿时间： | 2006-06-19 |
Correlations among expression of angiopietin-1 to clinical pathological characteristics an angio-genesis in oral squamous cell carcinoma |
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| Chao Li,Jian-chao Chen,Zhao-hui Wang,Bing Zhang,Bin Li,Yu-feng Song. Correlations among expression of angiopietin-1 to clinical pathological characteristics an angio-genesis in oral squamous cell carcinoma[J]. Chinese Journal of Cancer Research, 2006, 18(3): 198-202. DOI: 10.1007/s11670-006-0198-3 |
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| Authors: | Chao Li Jian-chao Chen Zhao-hui Wang Bing Zhang Bin Li Yu-feng Song |
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| Affiliation: | (1) Department of Head and Neck Surgery, Sichuan Cancer Hospital, Chengdu, 610041, China;(2) Department of Oral and Maxillary Surgery, The Affiliated Hospital, Guiyang Medical College, Guiyang, 550004, China |
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| Abstract: | Objective: To study the expression and the significance of Angiopoietin-1 (Ang-1) through observing the correlations among the expression of Ang-1 to clinicopathologic characteristics and microvessel density (MVD) in oral squamous cell carcinoma (OSCC). Methods: Expressions of Angiopoietin-1 and CD34 in 41 human OSCC tissues, 30 adjacent noncancerous oral tissues and 10 normal oral mucosas were detected by immunohistochemical SABC method. MCD was also assessed. Results: Of the 41 OSCC tissues, 41.46% (17/41) was Ang-1 positive. The expression of Ang-1 was significantly lower in OSCC than that in adjacent noncancerous oral tissues (P<0.05) and normal oral mucosa (P<0.05). The Ang-1 expression was significantly higher in high differentiated tumor than that in moderately differentiated tumor (P<0.05). The MVD was significantly higher in Ang-1-negative OSCC than in Ang-1-positive OSCC (P<0.01), and negatively correlated with the expression of Ang-1 (r=-0.32, P<0.05). Conclusion: Down-regulated expression of Ang-1 may play a crucial role in the development of OSCC. It negatively regulated the angiogenesis of tumor. |
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| Keywords: | Angiopoietin-1 (Ang-1) Mouth neoplasms Microvessel density (MVD) Angiogenesis |
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