| 清肾丸定性定量研究 |
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| 引用本文： | 王曙东,盛华,崔恩忠,唐安福,刘文雅,王争,汤淏.清肾丸定性定量研究[J].中南药学,2014(7):674-677. |
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| 作者姓名： | 王曙东 盛华 崔恩忠 唐安福 刘文雅 王争 汤淏 |
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| 作者单位： | 南京军区南京总医院制剂科,南京210002 |
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| 基金项目： | 全军医疗机构制剂标准提高科研专项课题重点项目（编号：13ZJZ13） |
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| 摘 要： | 目的建立清肾丸的定性定量方法。方法对方中当归、川芎、赤芍、红花4味药进行薄层色谱鉴别;采用高效液相色谱法对方中丹酚酸B进行含量测定。结果薄层色谱专属性强;丹酚酸B在12.53200.4μg·mL-1与峰面积呈良好的线性关系(r=0.999 9);低、中、高浓度平均回收率分别为98.8%、100.1%、99.0%(RSD分别为1.3%、1.5%、1.8%)。结论本文建立的定性定量方法简便,重现性好,准确可靠,可用于清肾丸的质量控制。
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| 关 键 词： | 清肾丸 定性定量方法 薄层色谱鉴别 高效液相色谱法 |
Qualitative and quantitative method of Qingshen pills |
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| WANG Shu-dong,SHENG Hua,CUI En-zhong,TANG.Qualitative and quantitative method of Qingshen pills[J].Central South Pharmacy,2014(7):674-677. |
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| Authors: | WANG Shu-dong SHENG Hua CUI En-zhong TANG |
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| Institution: | An-fu, LIU Wen-ya, WANG Zheng, TANG Hao (Depart- ment of Pharmaceutical Preparation, Nanjing General Hospital of Nanjing Military Command, PLA, Nanjing 210002) |
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| Abstract: | Objective To establish a qualitative and quantitative method for Qingshen pills.Methods A TLC method was used for the qualitative identification of Radix Angelicae Sinensis,Rhizoma Chanxiong,Radix Paeoniae Rubra and Flos Carthami,and HPLC method was used to determine salvianolic acid B.Results TLC spots were clear and specific.The linear relationship of salvianolic acid B content was good at 12.53-200.4 μg·mL-1（r = 0.999 9）.The average recovery was 98.8%,100.1% and 99.0%.RSD was 1.3%,1.5% and 1.8%.Conclusion The method is simple,accurate and reliable,and it can be used for the quality control of Qingshen pills. |
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| Keywords: | Qingshen pill quality standard TLC HPLC |
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