瑞舒伐他汀11例不良反应文献分析

目的了解瑞舒伐他汀致不良反应的情况,促进临床合理用药。方法采用文献计量学方法,对国内公开报道的11例瑞舒伐他汀不良反应病例进行总结性分析。结果瑞舒伐他汀致横纹肌溶解3例;致肌肉酸痛及下肢无力各1例;致CK及CK-MB升高1例;致肝损害2例;致包皮水肿1例;致勃起功能障碍1例;致发热1例。结论临床应重视瑞舒伐他汀发生的不良反应,用药时注意患者的临床表现。

Analysis of 11 adverse drug reactions of rosuvastatin

Objective To promote clinical rational drug safety by analyzing the adverse drug reaction（ADRs） caused by rosuvastatin.Methods Literature metrology was used,11 cases of ADRs by rosuvastatin reported in domestic literature were summarized.Results Rosuvastatin induced rhabdomyolysis 3 cases,muscle soreness and weakness of the lower limbs 1 case,CK and CK-MB 1 case,liver damage 2 cases,redundant prepuce edema 1 case,erectile dysfunction 1 case,fever 1 case.Conclusion Physicians should pay more attention to patient safety afer take rosuvastatin.