| 氨基胍对STZ糖尿病大鼠视网膜微血管病变的影响 |
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| 引用本文： | 庞东渤,符丽娟.氨基胍对STZ糖尿病大鼠视网膜微血管病变的影响[J].国际眼科杂志,2007,7(3):675-676. |
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| 作者姓名： | 庞东渤 符丽娟 |
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| 作者单位： | 1. 121001,中国辽宁省锦州市,辽宁医学院附属第一医院眼科
2. 121001,中国辽宁省锦州市,辽宁医学院药理教研室 |
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| 摘 要： | 目的:观察STZ糖尿病大鼠视网膜微血管病理改变及氨基胍对微血管病变的影响.方法:制备STZ糖尿病大鼠动物模型,随机分为正常对照(CON)组、糖尿病3mo(DM3)组,6mo(DM6)组,氨基胍3mo(AG3)组和6mo(AG6)组.每组大鼠各10只,分别饲养3,6mo.取大鼠视网膜进行视网膜微血管形态及超微结构观察.结果:DM组视网膜周细胞数目随病程逐渐减少,细胞核染色质浓缩,边集,分布于核膜下;胞质内线粒体肿胀,变性,空泡化,胞质消失,基底膜增厚.AG治疗组则明显改善.结论:氨基胍对STZ糖尿病大鼠视网膜微血管病变有防治作用.
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| 关 键 词： | 糖尿病视网膜病变 氨基胍 大鼠 氨基胍 糖尿病大鼠 视网膜 微血管病 影响 diabetic rats changes pathological retinal aminoguanidine 防治作用 改善 治疗组 增厚 基底膜 空泡 线粒体肿胀 胞质 膜下 分布 |
| 修稿时间： | 2007-03-072007-05-26 |
Influence of aminoguanidine on retinal microvascular pathological changes in diabetic rats |
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| Dong-Bo Pang,Li-Juan Fu.Influence of aminoguanidine on retinal microvascular pathological changes in diabetic rats[J].International Journal of Ophthalmology,2007,7(3):675-676. |
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| Authors: | Dong-Bo Pang Li-Juan Fu |
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| Institution: | 1 Department of Ophthalmology, the First Affiliated Hospital of Liaoning Medical University, Jinzhou 121001, Liaoning Province, China;2Staff Room of Pharmacology, Liaoning Medical University, Jinzhou 121001, Liaoning Province, China |
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| Abstract: | AIM:To observe pathological changes of retinal microv-ascular in diabetic rats and contribution of aminoguanidine.METHODS:Animal models of were induced by streptozotocin and randomly divided into diabetic mellitus(DM3) group,DM6 group,aminoguanidine(AG3) group,AG6 group and control group.The rats were killed after 6 months,their retinas were studied by light and electronic microscope.RESULTS:In DM group,the number of pericyte decreased and chromatin nucleolus concentrated,mitochondrion swelled and denaturalized,basement membrane thickened.The pathological changes of retina were improved in DM group.CONCLUSION:Aminoguanidine can effectively prevent and cure the damages of retinal capillary in stz-diabetic rats. |
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| Keywords: | diabetic retinopathy aminoguanidine rat |
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