泛发性结节性痒疹

报告1例泛发性结节性痒疹。患者男，26岁。2年前双大腿伸侧出现许多质地坚实的小丘疹，剧痒，并逐渐累及四肢及躯干，就诊前20d皮损突然增多、增大。皮损组织病理学检查示结节性痒疹样改变。免疫组化染色结果示S-100蛋白染色阳性的树突状细胞在表皮内显著增多，真皮内可见数量增多的嗜酸性粒细胞，S-100蛋白染色阳性的树突状细胞和神经结构，还有较多散在分布的富含颗粒的肥大细胞。抗酸染色示增生的表皮内可见大量抗酸染色阳性颗粒。

The generalized prurigo nodularis of the skin

A case of the rare prurigo nodularis is reported in this stody ,Male patient aged 26 developed a large amount of solid nodules on the extension side of thighs with severe pruritus two years ago,The skin lesions gradually advanced to exhospital visit .Some prurigo nodularis-like changes were found in the pathology examination of the lesions .Further immunopathological analysis demonstrated that the amount of S-100 stain positive dendritic cells significantly increased in the epidermis .In addition.the widespread infiltration of eosinophiles the S-100 stain positive dendritic cells .nerve stuctunes and some scattered mast cells with granules were easily seen in the dermis.Acid-fast slaining assay found a large amount of acid-fast stain positive granules in the cpidermis.