易卒中型肾血管性高血压大鼠肠系膜上动脉NPY能神经纤维的变化

用ABC免疫组化方法观察易卒中型肾血管性高血压大鼠术后7d、30d、90d三时期肠系膜上动脉神经肽Y能神经纤维的变化.①定性观察:对照组神经肽Y能神经纤维呈网状攀附于血管周围,分布较均匀,并见串珠状膨体;高血压组7d、30d神经纤维分布与对照组相似,90d纤维亦呈网状,但较稀疏.②定量结果:对照组各时期及高血压组7d、30d纤维密度无明显改变,但90d明显降低(P<0.01).结果显示,易卒中型肾血管性高血压大鼠肠系膜上动脉90d神经肽Y能神经纤维分布较稀疏,密度降低,其原因可能与血管壁结构的变化有关.

THE CHANGES OF NPY-CONTAINING NERVES ON THE SUPERIOR MESENTERIC ARTERIES IN TROKE-PRONE RENOVASCULAR HYPERTENSIVE RATS

The purpose of this study was to observe the changes of innervation NPY containing nerves on the wall of the superior measenteric arteries in stroke-prone renovascular hypertensive rats (RHRSP) in 7d, 30d and 90d by ABC immunohistochemical technique. The results were as follows: in the control group the NPY-containing fibers encircled the wall of the superior mesenteric arteries in reticulated shape and had strings of bulks; However, in the experimental group, the densityn of fibers was significantly decrease only in the late stage (90d, P<0.01). The results in this experiment suggested that the decrease of innervation on the wall of the superior mesenteric arteries may play a role in the development of renovascular hypertension.