Ultrastructural Features of Neuroendocrine Differentiated Carcinomas of the Breast |
| |
| Authors: | Carlo Capella Luciana Usellini Mauro Papotti Luigia Macri Giovanna Finzi Vincenzo Eusebi Gianni Bussolati |
| |
| Affiliation: | a Department of Human Pathology, University of Pavia, Varese, Italyb Department of Biomedical Sciences and Human Oncology, University of Turin, Turin, Italyc Institute of Pathological Anatomy and Histology, University of Bologna, Bologna, Italy |
| |
| Abstract: | The ultrastructural patterns of neuroendocrine (NE) differentiated breast carcinomas are analyzed and discussed. Reports in the literature describe wide variations in the size of observed dense-core membrane-bound granules and discrepancies in their interpretation. In the present study 24 cases of breast carcinoma with recognized morphologic, histochemical, and immunocytochemical features of NE tumors were investigated. Five different types of dense-core granules of neurosecretory (NS) type (confirmed by the ultrastructural localization of chromogranin A) and five different cell types were recognized. Some amphicrine cells were found to contain both mucin and NS granules. Another notable ultrastructural feature of breast NE carcinomas was the presence of clear vesicles of presynaptic type, which correlated with expression of synaptophysin. |
| |
| Keywords: | ultrastructure neuroendocrine breast neoplasms carcinoma clear vesicles chromogranin |
| 本文献已被 InformaWorld 等数据库收录！ |
|
