老年心力衰竭患者心功能与血浆B型钠尿肽和尿酸的相关性研究

目的探讨老年心力衰竭(CHF)患者心功能与血浆B型钠尿肽(BNP)和血尿酸的相关性。方法选择132例老年CHF患者作为CHF组,并按心功能分级(NYHA)Ⅰ级26例、Ⅱ级38例、Ⅲ级40例、Ⅳ级28例。同期选择健康体检者50例作为对照组。分别测定血浆BNP及血尿酸水平,比较不同心功能级别入选患者的血浆BNP水平和血尿酸水平。结果 CHF组患者血浆BNP和血尿酸水平明显高于对照组,差异有统计学意义[(784.19±206.00)ng/L vs(41.25±15.34)ng/L,(405.24±90.16)μmol/L vs(286.43±78.68)μmol/L,P<0.01];不同心功能分级患者血浆BNP和血尿酸水平两两比较,差异有统计学意义(P<0.05,P<0.01);CHF时,BNP与心功能分级、血尿酸、左心室舒张末内径(LVEDD)呈正相关(r=0.76、0.33、0.22,P<0.05);与LVEF呈负相关(r=-0.34,P<0.05);尿酸与心功能分级、LVEDD呈正相关(r=0.41、0.23,P<0.05);与LVEF呈负相关(r=-0.24,P<0.05)。结论血浆BNP和血尿酸水平与心功能分级可能具有相关性。

Correlation of heart function with plasma BNP and serum uric acid level in elderly heart failure patients

Objective To study the correlation of heart function with plasma BNP and serum uric acid(UA)levels in elderly heart failure patients.Methods One hundred and thirty-two elderly patients with chronic heart failure(CHF)served as a CHF group in this study.They were divided into classⅠgroup(n=26),classⅡ group(n=38),classⅢ group(n=40),and classⅣ group(n=28)according to the NYHA Classification.Fifty healthy subjects undergoing physical examination served as a control group.Their plasma BNP and erum UA levels were measured and compared.Results The plasma BNP and erum UA levels were significantly higher in CHF group than in control group(784.19±206.00ng/L vs 41.25±15.34ng/L,405.24±90.16μmol/L vs286.43±78.68μmol/L,P<0.01)and were significantly different in classⅠ-Ⅳ groups(P<0.05,P<0.01).The plasma BNP level was positively correlated with the NYHA Classification,serum UA level and LVEDD,and negatively correlated with the LVEF in CHF patients(r=0.76,0.33,0.22,P<0.05;r=-0.34,P<0.0 5).The serum UA level was positively correlated with the NYHA Classification and LVEDD,and negatively correlated with the LVEF in CHF patients(r=0.41,0.23,P<0.05;r=-0.24,P<0.05).Conclusion Plasma BNP and serum UA levels are correlated with the cardiac function classification in CHF patients.