调节性B淋巴细胞在自身免疫性疾病中的研究进展

自身免疫性疾病是指机体对自身成分产生免疫应答所致的一种疾病状态,这种自身免疫反应会影响相应器官的功能.在大多数自身免疫性疾病中,B淋巴细胞（简称B细胞）能产生自身抗体,因此一般被认为是自身免疫性疾病的”罪魁祸首”.最近大量研究发现,一类特殊的B细胞亚群即调节性B细胞（Bregs）能下调免疫反应,很好地维持免疫稳态,它们的丢失或缺乏会导致更加严重的自身免疫性疾病,且这种免疫调节功能主要通过自身分泌白细胞介素-10（IL-10）来实现.Bregs的起源、与其分化和功能相关的分子及其在自身免疫性疾病的作用将被进一步讨论.

The research progress of regulatory B cells in autoimmune diseases

Autoimmune diseases are induced by the immune responses to self-antigens.These diseases can impair the functions of a variety of organs.In the majority of autoimmune diseases,B cells are considered to be pathogenic because of their capacity to secrete autoantibodies.However,it has been found that a specific subset of B cells,termed as regulatory B cells（Bregs）,can downregulate immune responses in mice and maintain the fine balance required for immunotolerance.The absence or loss of Bregs result in exacerbated autoimmune responses.The origin of Bregs,the factors that are important for Bregs differentiation and for the function of their effector in autoimmune diseases are discussed in this review.