| 格列喹酮分散片的制备及质量控制 |
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| 引用本文： | 潘振华,曹德英,刘焕龙,向柏,方瑜.格列喹酮分散片的制备及质量控制[J].河北医科大学学报,2008,29(1):75-77. |
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| 作者姓名： | 潘振华 曹德英 刘焕龙 向柏 方瑜 |
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| 作者单位： | 1. 河北医科大学药学院药剂学教研室,河北,石家庄,050017
2. 河北医科大学第二医院药剂科,河北,石家庄050000 |
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| 摘 要： | 目的制备格列喹酮分散片,并建立格列喹酮分散片的溶出度测定方法。方法采用正交实验选择出交联聚乙烯吡咯烷酮为崩解剂,崩解剂内加和外加相结合的方法制成分散片,并对其热、湿、光等稳定性进行了考察。结果格列喹酮分散片工艺简单、稳定性良好,在1min内全部崩解,符合分散片的各项质量指标。结论本品达到分散片要求,制剂质量稳定。
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| 关 键 词： | 格列喹酮 质量控制 正交试验 |
| 文章编号： | 1007-3205（2008）01-0075-03 |
| 收稿时间： | 2007-03-20 |
| 修稿时间： | 2007-07-05 |
PREPARATION AND QUALITY CONTROL OF GLIQUIDONE DISPERSIVE TABLET |
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| PAN Zhen-hua,CAO De-ying,LIU Huan-long,XIANG Bai,FANG Yu.PREPARATION AND QUALITY CONTROL OF GLIQUIDONE DISPERSIVE TABLET[J].Journal of Hebei Medical University,2008,29(1):75-77. |
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| Authors: | PAN Zhen-hua CAO De-ying LIU Huan-long XIANG Bai FANG Yu |
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| Abstract: | Objective To prepare a fast action gliquidone dispersible tablets.MethodsCrospovidon was selected as disintegrants according to orthogonal test.The dispersible tablets were prepared by the combination of internal addition and external addition of disintegrants.The stability of the tablets was studied.ResultsThe tablets totally disintegrated within one minute,and their quality conformed to the standard.ConclusionThe tablets prepared can meet the require ment of dispersible tablets. |
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| Keywords: | gliquidone quality control orthogonal test |
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