| 急性运动心肌缺氧时线粒体膜损伤的实验研究 |
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| 引用本文： | 颜宜茝!100036,赵肖宪!100036,付小锁!100036,张勇. 急性运动心肌缺氧时线粒体膜损伤的实验研究[J]. 中国现代医药杂志, 1999, 0(1) |
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| 作者姓名： | 颜宜茝!100036 赵肖宪!100036 付小锁!100036 张勇 |
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| 作者单位： | 北京职工医学院生理教研室(颜宜茝!100036，赵肖宪!100036，付小锁!100036)，北京体育大学生物科学系(张勇) |
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| 摘 要： | 目的 研究急性耗竭运动缺氧应激后心肌线粒体膜结构和功能的变化.方法 采用递增负荷耗竭性运动为急性缺氧应激源,观察SD大鼠急性运动至力竭后心肌线粒体超微结构、线粒体膜过氧化脂质含量和线粒体内膜NADH-CoQ还原酶活性变化.结果 心肌能量需求过高性缺氧应激后大鼠心肌线粒体超微结构呈损伤性改变,线粒体膜过氧化脂质含量增高39.4%(P<0.05),线粒体内膜NADH-CoQ还原酶活性较安静时下降61.6%(P<0.05).结论急性运动心肌缺氧时线粒体膜结构及功能有明显改变.
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| 关 键 词： | 耗竭性运动 急性缺血 心肌线粒体膜 |
Experimental study of myocardial mitochondrial membraine damage resulting from hypoxia induced by acute exer-cise |
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| Yan Yichai,Zhao Xiaoxian,Zhang Yong,Fu Xiaosuo Beijing ,Dept. of Physiology,BeijingMedical Staff College. Experimental study of myocardial mitochondrial membraine damage resulting from hypoxia induced by acute exer-cise[J]. Modern Medicine Journal of China, 1999, 0(1) |
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| Authors: | Yan Yichai Zhao Xiaoxian Zhang Yong Fu Xiaosuo Beijing Dept. of Physiology BeijingMedical Staff College |
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| Affiliation: | Yan Yichai,Zhao Xiaoxian,Zhang Yong,Fu Xiaosuo Beijing 100036,Dept. of Physiology,BeijingMedical Staff College |
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| Abstract: | ve To study the ultrastructural and functional changes in myocardial mitochondrialmembrane after hypoxia induced by acute exhaustive exercise.Mathode SD rats were used as experimental animalsto investigat ischemic effects of hypoxia by incremental exercise intensity on ultrastructures and functions of my-ocardial mitochondria. Results The ultrastructures of myocardial mitochondria were injured, the MDA content ofmyocardial mitochondria increased 39.4% and the activity of NADH-CoQ reductase in respiratory chain declined61 .6% in experimental exhaustive rats. Conclusion The ultrastructural and functional changes of myocardial mi-tochondrial membrane were remarkable after hypoxia induced by acute exhaustive exercise. |
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| Keywords: | Exhaustive exercise Acute ischemia Myocardial mitochondria |
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