Genetic distinctions between autoimmune hepatitis in Italy and North America |
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Authors: | Muratori Paolo Czaja Albert-J Muratori Luigi Pappas Georgios Maccariello Silvana Cassani Fabio Granito Alessandro Ferrari Rodolfo Mantovani Vilma Lenzi Marco Bianchi Francesco-B |
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Institution: | 1. Deparunent of Internal Medicine,Cardioangiology, Hepatology, University of Bologna 2. Division of Gastroenterology and Hepatology,Mayo Clinic and Mayo Foundation, Rochester, MN, USA 3. Laboratorio Centralizzato Settore Genetica,University of Bologna |
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Abstract: | AIM: Our goals were to analyze the known genetic predispositions for autoimmune hepatitis (AIH) in AIH Italian population and to compare them with North American counterparts. METHODS: Human leukocyte antigens (HLA) B8, C7, DR3, DR4, DR7, DR11, DR13, DQ2 and the B8-DR3-DQ2 phenotype were determined by microlymphocytotoxicity and polymerase chain reaction in 74 Italian patients (57 with type 1 and 17 with type 2 AIH) and 149 North American patients with type 1 AIH, and in adequate controls. RESULTS: B8-DR3-DQ2 occurred more frequently in Italian patients with type 1 AIH than in Italian controls (30% vs 7%, P<0.0001), but less frequently than in North American counterparts (30% vs 48%, P= 0.02). DR4 occurred less frequently in Italian patients with type 1 AIH (23% vs 43%, P= 0.01) and in controls (16% vs 34%, P= 0.0003) than in North American counterparts. No differences were found in alleles' frequency between type 1 and type 2 Italian AIH patients. DR11 had a frequency lower in type 1 Italian AIH patients than controls (17% vs 35%, P= 0.01). CONCLUSION: HLA DR4 is not associated with AIH in Italy. The known HLA risk factors for AIH occur similarly in Italian patients with type 1 and type 2 AIH, and they are less frequent than in North American patients. B8-DR3-DQ2 is the predominant phenotype of type 1 AIH also in Italy, and HLA DR11 may be a regionally distinctive protective factor against type 1 AIH. |
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Keywords: | Type 1 autoimmune hepatitis Type 2 autoimmune hepatitis Human leukocyte antigen |
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