HSP70、IL-18和S100B水平与脑出血预后的关系研究

目的探讨高血压性脑出血患者血浆及脑脊液热休克蛋白70（HSP70）、IL-18和S100B水平与预后的关系。方法对65例高血压性脑出血患者采用ELISA法检测血浆及脑脊液HSP70、IL-18和S100B水平，统计分析其与患者预后的相关性。结果血浆及脑脊液HSP70、IL-18和S100B水平与高血压性脑出血患者入院时GCS评分、血肿量、脑室积血及生存率均有显著相关性（均P〈0．05）；血浆及脑脊液HSP70、IL-1吕和SIOOB水平对脑出血后1周内死亡均有显著预测价值（均P〈0．05），且有较高或中等的特异度和灵敏度，血浆及脑脊液S100B水平与入院时GCS评分及血肿量曲线下面积的差异无统计学意义（P〉0．05）。血浆及脑脊液HSP70和IL-18水平较入院时GCS评分及血肿量曲线下面积显著减少（均P〈0．05）。结论HSP70、IL-18和S100B共同参与了高血压性脑出血的病理生理过程，临床检测这些指标有助于早期判断高血压性脑出血患者的预后，S100B水平预测脑出血死亡有较高应用价值。

Correlation of HSP70,IL-18 and S100B levels in plasma and cerebrospinal fluid with the outcome of hypertensive intracerebral hemorrhage

Objective To investigate the correlation of HSP70, IL-18 and SIOOB in plasma and cerebrospinal fluid （CSF） with the prognosis of patients with hypertensive intracerebral hemorrhage （HICH）. Methods Sixty-five patients with HICH were included in the study. Concentrations of HSP70, IL-18 and S100B in plasma and CSF were measured by ELISA. Results The HSP70, IL-18 and S100B in plasma and CSF were highly associated with GCS score, hematoma volume, presence of intraventricular hemorrhage （IVH） and survival rate in HICH （all P〈0.05）. The concentrations of HSP70, IL-18 and S100B in plasma and CSF showed high prediction value in mortality of 1-week period after intracerebral hemorrhage （all P〈0.05）. There was no significant difference between the areas under the ROC curve of S100B in plasma and CSF and that of GCS scores and hematoma volume （P〉0.05）, while the areas under the ROC curve of HSP70 and IL-18 decreased significantly （all P〈0.05）. Conclusion HSP70, IL-18 and S100B might be associated with pathogenesis of hypertensive intracerebral hemorrhage; their levels in plasma and CSF can be used to predict the outcome of HICH.