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| 喉癌组织中E-钙黏附素mRNA的表达及意义 | |
| 引用本文： | 吴正虎,曹晓林,刘亭彦,吴建峰.喉癌组织中E-钙黏附素mRNA的表达及意义[J].浙江医学,2006,28(5):321-322,352. |
| 作者姓名： | 吴正虎 曹晓林 刘亭彦 吴建峰 |
| 作者单位： | 1. 310015,杭州师范学院附属医院、杭州市第二人民医院 2. 杭州市第一人民医院 3. 浙江省新华医院 |
| 摘 要： | 目的探讨E-钙黏附素（E-CD）mRNA在喉鳞状细胞癌中的表达及其与喉癌发生发展的关系.方法应用逆转录聚合酶链反应技术对43例喉癌和23例癌旁正常黏膜组织中的E-CD mRNA表达进行检测,并分析检测结果与临床病理因素的关系.结果与癌旁正常黏膜组织相比,喉癌组织中E-CD mRNA表达指数明显降低（P＜0.01）,并与颈淋巴结转移、肿瘤大小（T分期）、临床分期、肿瘤组织分化程度相关,颈淋巴结转移者低于无颈淋巴结转移者（P＜0.01）,T3-4低于T1-2（P＜0.05）,Ⅲ～Ⅳ期低于Ⅰ～Ⅱ期（P＜0.01）,中分化喉癌组织低于高分化组织（P＜0.05）.结论E-CD mRNA低表达与喉癌发生发展相关. |
| 关 键 词： | 喉肿瘤 E-钙黏附素 逆转录聚合酶链反应 |
| 收稿时间： | 2006-02-15 |
| 修稿时间： | 2006-02-15 |
Expression of E-cadherin mRNA in squamous cell carcinoma of the larynx |
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| WU Zhenghu,CAO Xiaolin,LIU Tingyan,et al..Expression of E-cadherin mRNA in squamous cell carcinoma of the larynx[J].Zhejiang Medical Journal,2006,28(5):321-322,352. | |
| Authors: | WU Zhenghu CAO Xiaolin LIU Tingyan |
| Institution: | Department of Otolaryngology, Affiliated Hospital of Hangzhou Normal College, Hangzhou 310015, China |
| Abstract: | Objective To study the expression level of E-cadherin (E-CD) mRNA in laryngeal carcinoma and its relation to biological behavior . Methods The level of E-CD mRNA expression was examined by RT-PCR in 43 specimens of squamous cell carcinoma of larynx and 23 specimens of pericancerous tissue. Results All the specimens of laryngeal carcinoma expressed E-CD mRNA, and the expression level in primary tumors was significantly decreased compared with that in pericancerous tissues(P<0.01). There was a significant correlation between decreased E-CD mRNA expression and the presence of nodal metastases(P<0.01), T stage(P<0.05),clinical stage (P<0.01) and histological grade (P<0.05). Conclusion The study provides evidence that E-CD may be related to progression and differentiation of laryngeal cancer. |
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