Effect of vacuum curettage on the concentrations of plasma 6-keto-prostaglandin Flα and serum thromboxane B2 |
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| Authors: | O YLIKORKALA U-M MÄKILÄ L VIINIKKA |
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| Institution: | Departments of Obstetrics and Gynaecology and Clinical Chemistry, University of Oulu, Oulu, Finland |
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| Abstract: | Summary. Serial plasma samples collected before and after vacuum curettage followed by methylergometrine injection in 10 women were assayed for 6-keto-prostaglandin Flα (6-keto-PGF1α). The mean 6-keto-PGFlα concentration was 97.2 (SE 8.8) pg/ml before cervical dilatation. The concentration rose to 128.2 (SE 13.5) pg/ml (P < 0.10) immediately and to 133.3 (SE 17.8) pg/ml (P < 0.05) 1 h after curettage and returned to the initial value within 5 h. Neither methylergometrine nor anaesthesia, nor non-gynaecological surgery, caused changes in the level of plasma 6-keto-PGFlα. The capacity of the platelets to produce thromboxane A2 during spontaneous clotting of blood did not change during vacuum curettage, anaesthesia and non-gynaecological surgery, nor after methylergometrine. The evidence suggests that the pregnant myometrium and/or intrauterine tissues capable of generating prostacyclin (PGI2) in vitro may release PG12 also in vivo . |
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