Five novel prenylated xanthones from Resina Garciniae |
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| Authors: | FENG Feng WEN-YUAN Liu YOU-SHENG Chen QING-LONG Guo QI-DONG You |
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| Affiliation: | a Department of Phytochemistry, China Pharmaceutical University, Nanjing, Chinab Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing, Chinac Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, Chinad Department of Physiology, China Pharmaceutical University, Nanjing, China |
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| Abstract: | Fourteen prenylated xanthone derivatives were isolated from gamboge, the dry latex of Garcinia hanburyi, and their structures were elucidated by a detailed spectroscopic analysis. Five of them, isogambogenic acid (1), desoxymorellinin (2), 10-methoxygambogenic acid (3), 10-methoxygambogic acid (4) and 10-ethoxy gambogic acid (5), are new compounds. All of them showed potent cytotoxicity against HL-60, SMMC-7721 and BGC-83 cells. |
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| Keywords: | Resina Garciniae Guttiferae Prenylated xanthone Isogambogenic acid Desoxymorellinin 10-methoxygambogenic acid |
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