| 非小细胞肺癌组织Bmi-1与C-myc蛋白表达及其相关性 |
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| 引用本文： | 项锋钢,党受琴,冉雯雯,李宏.非小细胞肺癌组织Bmi-1与C-myc蛋白表达及其相关性[J].青岛大学医学院学报,2011,47(3):204-206,209. |
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| 作者姓名： | 项锋钢 党受琴 冉雯雯 李宏 |
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| 作者单位： | 青岛大学医学院病理学教研室,山东,青岛,266021 |
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| 摘 要： | 目的探讨Bmi-1与C-myc蛋白在非小细胞肺癌(NSCLC)组织表达及其与临床病理特征关系,进一步评价二者在NSCLC发生、发展中作用及其之间相关性。方法应用免疫组织化学SP法,检测52例NSCLC及30例远癌正常肺组织Bmi-1和C-myc蛋白表达情况。结果肺癌组织Bmi-1和C-myc蛋白的阳性表达率分别为67.3%(35/52)、75.0%(39/52),均明显高于正常肺组织的13.3%(4/30)、6.7%(2/30),且阳性表达强度差异有显著性(Z=-4.837、-5.907,P0.01);肺癌组织中Bmi-1及C-myc蛋白阳性表达均与癌组织的TNM分期及有无淋巴结转移有关(Z=-2.596~-2.056,P0.05),而与病人的性别、年龄、组织类型等无关(Z=-1.775~-0.382,P0.05);C-myc蛋白阳性表达还与癌组织的分化程度有关(Z=-2.056,P0.05),而Bmi-1蛋白阳性表达与其无关。肺癌组织中二者表达呈显著正相关(r=0.463,P0.01)。结论 Bmi-1与C-myc蛋白在NSCLC发生发展、浸润转移中发挥着重要作用。
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| 关 键 词： | 癌 非小细胞肺 Bmi- C-myc 免疫组织化学 |
EXPRESSIONS OF Bmi-1 AND C-myc PROTEINS IN NON-SMALL CELL LUNG CANCER AND THEIR CORRELATION |
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| XIANG FENG-GANG,DANG SHOU-QIN,RAN WEN-WEN,LI HONG.EXPRESSIONS OF Bmi-1 AND C-myc PROTEINS IN NON-SMALL CELL LUNG CANCER AND THEIR CORRELATION[J].Acta Academiae Medicinae Qingdao Universitatis,2011,47(3):204-206,209. |
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| Authors: | XIANG FENG-GANG DANG SHOU-QIN RAN WEN-WEN LI HONG |
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| Institution: | XIANG FENG-GANG,DANG SHOU-QIN,RAN WEN-WEN,LI HONG(Department of Pathology,Qingdao University Medical College,Qingdao 266021,China) |
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| Abstract: | Objective To investigate the expressions of Bmi-1 and C-myc in non-small cell lung cancer(NSCLC),explore their relationship with the clinical pathology,and assess the effect of the two parameters on the occurrence and development of this lung malignancy.Methods Expressions of Bmi-1 and C-myc proteins were detected by immunohistochemical SP method in 52 samples of NSCLC and 30 normal tissue samples that far away from cancer.Results The positive expression rates of Bmi-1 and C-myc in the cancer tissue were 67... |
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| Keywords: | Bmi-1 C-myc |
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