| 食蟹猴年龄相关性学习记忆减退与海马结构的突触素改变 |
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| 引用本文： | 吴玉娥,李文德,闵凡贵,谭文雅,潘金春,黄韧.食蟹猴年龄相关性学习记忆减退与海马结构的突触素改变[J].中风与神经疾病杂志,2010,27(7). |
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| 作者姓名： | 吴玉娥 李文德 闵凡贵 谭文雅 潘金春 黄韧 |
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| 作者单位： | 1. 广东省实验动物监测所(广东省实验动物重点实验室),广东,广州,510260
2. 广东医学院药理教研室,广东,湛江,524023 |
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| 基金项目： | 广东省自然科学基金项目(06023013,010086); 广东省科技计划项目(2006B36004015,2009B060300017) |
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| 摘 要： | 目的观察老年学习记忆减退食蟹猴海马结构突触素表达的变化。方法 8只雌性食蟹猴,分为青年和老年两组,用延迟反应实验测试两组食蟹猴的空间学习记忆能力,用免疫组织化学技术显示突触素在海马结构中的表达变化。结果老年组食蟹猴在延迟反应实验中各延迟时间(10s、15s、30s、60s)的选择正确率较青年组显著降低(P<0.01),老年组海马结构突触素免疫反应物平均光密度值较青年组显著降低(P<0.01)。结论老年食蟹猴学习记忆能力减退,海马结构突触素表达降低,提示老年学习记忆能力与海马结构突触素有密切联系。
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| 关 键 词： | 学习记忆减退 突触素 海马 食蟹猴 |
Change of hippocampal synaptophysin in aged learning ang memory deficits of cynomolgus |
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| WU Yu-e,LI Wen-de,MIN Fan-gui,et al..Change of hippocampal synaptophysin in aged learning ang memory deficits of cynomolgus[J].Journal of Apoplexy and Nervous Diseases,2010,27(7). |
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| Authors: | WU Yu-e LI Wen-de MIN Fan-gui |
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| Institution: | WU Yu-e,LI Wen-de,MIN Fan-gui,et al. (Guangdong Laboratory Animals Monitoring Institute,Guangzhou 510260,China) |
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| Abstract: | Objective To study the relationship between the aged cynomolgus learning and memory deficits and the synaptophysin immunolabeling density of the hippocampal formation. Methods We trained 8 female cynomolgus to perform the delayed-response task and monkeys were tested after reaching criterion on the task. The synaptophysin (SYP) immunolabeling density was estimated in paraffin sections of hippocampal formation of cynomolgus. Results The performance of the aged monkeys in delayed-response was significantly re... |
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| Keywords: | Aged learning and memory deficits Synaptophysin Hippocampus Cynomolgus |
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