反应停与柳氮磺胺吡啶联合治疗强直性脊柱炎的临床研究

[目的]探讨治疗强直性脊柱炎（AS）的有效性、安全性方法。[方法]AS患者102列,随机分成4组,A组（反应停＋SASP）26例、B组（反应停）24例、C组（SASP）25例、D组（非甾体抗炎药NASAIDS）27例。观察治疗前后晨僵时间、外周关节痛指数、指地距、枕墙距、血沉（ESR）、C反应蛋白（CRP）等指标变化。比较4种治疗方案的临床疗效及副反应。[结果]晨僵时间、外周关节痛指数、指地距、枕墙距、血沉（ESR）、C反应蛋白（CRP）等指标与治疗前相比差异显著,各组总有效率为65.4%、50.0%、32.0%、14.8%。不良反应反应停联合组明显低于SASP组28.0%和NASAIDS组48.1%（P〈0.05）。[结论]反应停与SASP联合治疗AS比单用反应停SASP和NASAIDS疗效显著,不良反应轻。

Ankylosing Spondylitis Treated with Thalidomide and Sulfasalazine

[Objective]To evaluate the curative effect and safty of thalidomide and sutfasalazine on ankylosing spondylitis（AS）. [Method]102 cases were admitted to the study and were randomized into four groups：26 cases in group A（treated with thalidomide and SASP）, 24 cases in group B（ treated with thalidomide）, 25 cases in group C（treated with SASP）, 27eases in group D （treated with NASAIDS）. Six months are a course, the patients＇ condition of four groups was similar. Group A and Group B were voluntary and excluded pregnancy and no-breed. Observe the change of the time of morning stiff,joint press pain-index, fingertip to floor distance, the distance between occipital to the wall, ESR and C-reactive protein after the treatment. Compare the effect and adverse reaction of these treatments. [Results]There were differences on morning stiffness time ,joint press pain-index, fingertip to floor distance, the distance between occipital to the wall,ESR and C-reactive protein through those treatments. The total effective rate of each group was 65.4 %, 50.0 %,32.0 %, 14.8 % respectively, there was significant difference between group A and other groups,no difference between group C and group D. The side effects of treatment were drowsiness and gastrointestinal indisposition and it was usually temporary. The incidence rate of those side effects was 15.4%, which was lower than group C（28. 0 %） and group D（48.1% ）. The leucocyte decreased and aminopherase increased were not incidence in group A and group B. [Conclusion]Treating ankylosing spondylitis with thalidomide and sulfasalazine was better than with thalidomide, sulfasalazine or NASAIDS alone. Some side effects were incidences but lightly.