| DDPH对多种物质所致豚鼠离体胆囊平滑肌收缩的抑制作用 |
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| 引用本文： | 胡国胜,黄先菊. DDPH对多种物质所致豚鼠离体胆囊平滑肌收缩的抑制作用[J]. 中国现代应用药学, 1998, 15(6): 18-21 |
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| 作者姓名： | 胡国胜 黄先菊 |
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| 作者单位： | 湖北省职工医学院荆州 434000 |
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| 摘 要： | 目的:研究DDPH对多种物质所致离体胆囊平滑肌收缩的抑制作用。方法:离体胆囊平滑肌实验方法。结果:组胺、乙酰胆碱、CaCl_2均可引起胆囊收缩,其收缩量效曲线的pD_2值分别为5.35、7.22和3.04,不同浓度的DDPH可压低这些物质引起的胆囊收缩量效曲线,其pD值分别为3.70、4.31和4.03。DDPH和维拉帕米均能抑制K~ 所致胆囊平滑肌收缩,它们的IC_(50)值分别为11.22和3.16pmol·L~(-1)。结论:DDPH对胆囊平滑肌有较好的松驰作用。
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| 关 键 词： | 胆囊 DDPH 磷酸组胺 氯化乙酰胆碱 氯化钙 维拉帕米 |
| 修稿时间： | 1997-10-05 |
Inhibitory effects of DDPH on contraction of isolated gallbladder of guinea pigs induced by some materials |
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| Hu Guosheng(Hu GS,Huang Xianju ( Huang XJ. Inhibitory effects of DDPH on contraction of isolated gallbladder of guinea pigs induced by some materials[J]. The Chinese Journal of Modern Applied Pharmacy, 1998, 15(6): 18-21 |
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| Authors: | Hu Guosheng(Hu GS Huang Xianju ( Huang XJ |
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| Abstract: | OBJECTIVE: To investigate the effects of DDPH on contraction of isolated gallbladder of guinea pigs induced by some materials. METHODS: The experimental method of the isolated smooth muscle of the gallbladder. RESULTS: Histamine, acetylcholine and CaCl2 c |
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| Keywords: | gallbkdder DDPH histamine acetylcholine calium chloride verapamil |
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