| 高氟对大鼠心肌电生理及心电图的影响 |
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| 引用本文： | 宋术亮 边建朝. 高氟对大鼠心肌电生理及心电图的影响[J]. 地方病通报, 2000, 15(1): 11-12 |
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| 作者姓名： | 宋术亮 边建朝 |
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| 作者单位： | 山东省地方病防治研究所 |
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| 摘 要： | 为观察高氟对大鼠心肌电生理及心电图的影响,给两组（每组１０只）Ｗｉｓｔａｒ大鼠饲喂正常饲料,分别饮用１．５８ｍｍｏｌ／Ｌ,２．６３ｍｍｏｌ／Ｌ高氟水。;实验８个月时测定尿氟含量;描记心电图;处死动物行心肌电生理检查,同时留取血清测氟含量。结果显示：两组大鼠尿氟,血清氟含量升高;心肌细胞动作电位的ＲＰ,ＡＰＡ均降低,Ｖｍａｘ减慢,ＡＰＤ５０,ＡＰＤ９０均缩短;心电图Ｔ波振幅降低,Ｑ－Ｔ间期缩短。高氟
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| 关 键 词： | 氟 心电图 心肌电生理 |
Effect of Fluorosis on Electrophysiology of Myocardial Cells and Electrocardiogram of the Rats |
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| SONG Shu liang,BIAN Jian chao,XIANG You zhang,et al. Effect of Fluorosis on Electrophysiology of Myocardial Cells and Electrocardiogram of the Rats[J]. Endemic Diseases Bulletin, 2000, 15(1): 11-12 |
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| Authors: | SONG Shu liang BIAN Jian chao XIANG You zhang et al |
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| Abstract: | In order to observe the effect of fluorosis on the electrophysiology of myocardial cells (EMC) and electrocardiologram (ECG) of the rats, 20 Wistar rats was fed with normal fodder and high concentration NaF(1.58,2.63 mmol/L, F) for 8 months. The results showed that there was an inerease of urinary F and serum F; the RP and APA were lower. Vmax was slower and APD 50 and APD 90 were shorter on the EMC; the amplitude of T wave was lower and Q-T interval was shorter on the ECG. Fluorosis can cause myocardial cell damage and result in changes of EMC and ECG in the rats. |
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| Keywords: | Fluorosis Rats EMC and ECG |
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