| 蛋白激酶C在大鼠小肠缺血预处理中的作用 |
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| 引用本文： | 刘秀华,庞永正,常英姿,苏静怡,唐朝枢. 蛋白激酶C在大鼠小肠缺血预处理中的作用[J]. 北京大学学报(医学版), 1996, 0(2) |
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| 作者姓名： | 刘秀华 庞永正 常英姿 苏静怡 唐朝枢 |
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| 作者单位： | 北京医科大学心血管基础研究所病理生理研究室 |
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| 摘 要： | 目的：探讨蛋白激酶Ｃ（ＰＫＣ）在大鼠小肠缺血预处理中的作用。方法：采用大鼠小肠原位灌流的缺血再灌注（Ｉ／Ｒ）模型，观察ＰＫＣ抑制剂ＰｏｌｙｍｙｘｉｎＢ和Ｈ＿７对缺血预处理（ＰＣ）的肠道组织及血管床保护作用的影响。结果：ＰＣ明显减轻了Ｉ／Ｒ后肠粘膜病理损伤、ＭＤＡ产生、ＩＤＨ漏出（Ｐ＜０．０１），并减少了肠道微血管壁对伊文思兰的渗出（Ｐ＜０．０１）。ＰｏｌｙｍｙｘｉｎＨ和Ｈ＿７完全阻断了这种保护作用。结论：缺血预处理对Ｉ／Ｒ的小肠组织和血管床有保护作用，其机理涉及ＰＫＣ的激活。
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| 关 键 词： | 肠，小／血液供应；再灌注损伤／病理生理学；蛋白激酶C／药理学 |
ISCHEMIC PRECONDITIONING PROTECTS INTESTINE AGAINST ISCHEMIA REPERFUSIN INJURY BY PROTEIN KINASE C ACTIVATION |
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| LIUXiuhua,PANGYongzheng, CHANGYingzi, SUJingyi, TANGCbaoshu. ISCHEMIC PRECONDITIONING PROTECTS INTESTINE AGAINST ISCHEMIA REPERFUSIN INJURY BY PROTEIN KINASE C ACTIVATION[J]. Journal of Peking University. Health sciences, 1996, 0(2) |
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| Authors: | LIUXiuhua PANGYongzheng CHANGYingzi SUJingyi TANGCbaoshu |
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| Affiliation: | Institute of Cardiovascular Research. Beijing Medical University 100083 |
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| Abstract: | Objective:To invextigate the effect of PKC on ischemic preconditioning(IPC) of rat intes-tine.Methods:On the model of in situ intestinal ischemia/reperfusion (I/R) injury of rat. the effeets of PolvmvxinBand H-(PKC inhbitors ) on intestinaltissue and vasculature protection of IPC were ob-served. Results:IPC signifleantly.attenuated intestinal mueosal lesionand leakage of LDH.CD.low-ered inerease of MDA content in intestinal tissue and vaseular permeability to Evans blue dve.These protective effeets were completly.abolished by administration of PKC inhibitor .Polymysin B or H_7. Conclusion:IPC Droteets intestinal tissue and vasculature from 1/R injury and these protective effeets are mediated by PKCaetivation. |
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| Keywords: | HeadingsIntestine small /bloodsupply Reperfusion injury/physiopathol Protein kinaseC/ pharmacol |
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