Different patterns of molecular forms of somatostatin are released by the rat median eminence and hypothalamus |
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Authors: | A R Pierotti A J Harmar L A Tannahill G W Arbuthnott |
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Affiliation: | MRC Brain Metabolism Unit, University Department of Pharmacology, 1 George Square, Edinburgh EH8 9JZ U.K. |
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Abstract: | The molecular forms of somatostatin (SOM) released from hypothalamic slices and from the isolated median eminence (ME) in vitro were compared by high-performance liquid chromatography and radioimmunoassay. SOM-14 was the predominant form of the peptide released from hypothalamic slices, although small amounts of SOM-28 were detected. Perifusates of ME tissue contained a larger proportion of SOM-28 and higher molecular weight peptides were present; depolarization increased the rates of release of all molecular forms of SOM. These results suggest that the capacity to release SOM-28 and high-molecular-weight forms of SOM may be a specialized function of nerve terminals in the ME. |
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Keywords: | somatostatin-14 somatostatin-28 hypothalamus median eminence release high-performance liquid chromatography rat |
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