The dexamethasone suppression test in depressed retarded adults: preliminary findings |
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| Authors: | B E Beckwith L Parker D Pawlarczyk D I Couk K S Schumacher K Yearwood |
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| Affiliation: | 1. Humane Rescue Alliance, 71 Oglethorpe Street NW, Washington, DC 20011, United States of America;2. Department of Environmental Science and Policy, College of Science, George Mason University, 4400 University Drive, Fairfax, VA 22030, United States of America;3. North Carolina Museum of Natural Sciences, 11 W Jones Street, Raleigh, NC 27601, United States of America;4. Smithsonian Conservation Biology Institute, 1500 Remount Road, Front Royal, VA 22630, United States of America;5. Appalachian Laboratory, University of Maryland Center for Environmental Science, 301 Braddock Rd., Frostburg, MD 21532, United States of America;1. U.S. Geological Survey, Wetland and Aquatic Research Center, 7920 NW 71 St., Gainesville, FL 32653, United States;2. Department of Wildlife Ecology and Conservation, University of Florida, PO Box 110430, Gainesville, FL 32611, United States;3. Department of Wildlife Ecology and Conservation, , University of Florida, 3205 College Ave., Fort Lauderdale, Florida 33314, United States;4. U.S. Geological Survey, Wetland and Aquatic Research Center, 700 Cajundome Blvd., Lafayette, AL 70506, United States;5. U.S. Geological Survey, Fort Collins Science Center, 2150 Centre Ave., Bldg. C, Fort Collins, CO 80526, United States;6. Sam Noble Museum and Biology Department, University of Oklahoma, Norman, OK 73072, United States;1. Department of Forestry and Natural Resources, Purdue University, 195 Marsteller Street, West Lafayette, IN 47909, USA;2. School of Public and Community Health Sciences, University of Montana, 32 Campus Drive, Missoula, MT 59812, USA;3. Seattle City Light, Environment, Land and Licensing, 700 5th Ave, Seattle, WA 98124, USA;4. USDA Forest Service Region 1, Missoula, MT 59804, USA;5. Franke College of Forestry and Conservation, Wildlife Biology Program, University of Montana, Missoula, MT 59812, USA;1. U.S. Geological Survey, Southwest Biological Science Center, Grand Canyon Monitoring and Research Center, 2255 N. Gemini Dr. Flagstaff, AZ 86001, USA;2. University of California, 1 Shields Avenue Davis, CA 95616, USA;3. University of Alaska Anchorage, 3211 Providence Drive, Anchorage, AK 99508, USA;4. RAND Corporation, 1200 S. Hayes St. Arlington, VA 22202, USA;5. U.S. Fish and Wildlife Service, PO Box 346, Bethel, AK 99559, USA |
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| Abstract: | This study was undertaken to determine the utility of the Dexamethasone Suppression Test (DST) for diagnosing depression in institutionalized mentally retarded persons. Depressed and nondepressed institutionalized mentally retarded persons were given 1 mg dexamethasone for an overnight DST. Serum cortisol concentrations greater than 4 micrograms/dl at both 8:00 AM and 4:00 PM provided discrimination of depressed from nondepressed groups. Also, using the criteria of serum cortisol concentrations greater than 4 micrograms/dl at 8:00 AM and 4:00 PM, at 4:00 PM and 10:00 PM, or at 8:00 AM, 4:00 PM, and 10:00 PM differentiated these groups. These results suggest that the DST may be useful for detecting melancholia among institutionalized retarded persons. |
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