The immune function injury and its mechanism in drug abuser |
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作者姓名: | 何德 刘仿 等 |
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摘 要: |
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关 键 词: | 药物滥用 免疫功能 T细胞亚群 细胞因子 一氧化氮 药物依赖 |
The immune function injury and its mechanism in drug abuser |
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Institution: | GuangdongMedicalCollege,Zhanjiang524023,China |
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Abstract: | Objective:To explore the immune function injury and its mechanism in drug abuser.Methods:The immune function changes in 50 drug abusers were compared with normal healthy populations by detection of the indexes of subgroups of Th cells,transformation rate of lymphocytes,IgA,IgM,IgG,IgE,compliment C3,C4,IL-1,Il-2,IL-6 TNF and NO.Result:In peripheral blood the percentage of Th1 cell,transformation rate of lymphocyte,IgA,IgM,IgG,IgE content,compliment C4,C4,IL-1,IL-2,IL-6,and TNF levels were significantly lower than normal (P&;lt;).01).The value of Th1/Th2 was lower than normal as well(P&;lt;0.05).NO content was significantly higher than normal (P&;lt;0.001).Conclusion:The mechanism of immune function injury in drug abuser might be correlative to direct injury of drugs and their inhibition effect on the thymus-hypothalamus-hypophysis-adrenal axis. |
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