| HIV感染者体内抗小分子多肽抗体与病情发展的初步研究 |
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| 引用本文： | 徐小元,邢卉春,公维波,陈红梅,斯崇文,王艳,J.C Chermann.HIV感染者体内抗小分子多肽抗体与病情发展的初步研究[J].中华实验和临床病毒学杂志,2002,16(3):286-287. |
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| 作者姓名： | 徐小元 邢卉春 公维波 陈红梅 斯崇文 王艳 J.C Chermann |
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| 作者单位： | 1. 100034,北京大学第一医院感染疾病科
2. France,INSERMU322 |
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| 基金项目： | 法国INSERMU3 2 2，北京市自然科学基金 (70 2 2 0 19) |
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| 摘 要： | 目的 研究HIv感染者体内抗—R7v含量与病情发展的关系。方法 用ELISA、中和沉淀等方法检测HIv感染者、长期生存者、艾滋病患者等的抗—R7v含量。结果 抗—R7v检出率在无症状组和长期生存组较高，在进展者和艾滋病患者中较低，溶解处理标本后抗—R7v含量及阳性率明显提高。结论 抗—R7V主要通过于扰HIV与CCB5、CxCR4结合，使HIV不能进入CD4^ T淋巴细胞内，并阻止病毒的复制。
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| 关 键 词： | HIV感染 多肽抗体 病情发展 趋化因子受体 |
| 修稿时间： | 2002年4月10日 |
Preliminary investigation on the relation between clinical progress and anti-small monomolecular peptides antibody in individual infected with HIV |
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| J.C Chermann.Preliminary investigation on the relation between clinical progress and anti-small monomolecular peptides antibody in individual infected with HIV[J].Chinese Journal of Experimental and Clinical Virology,2002,16(3):286-287. |
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| Authors: | JC Chermann |
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| Institution: | Department of Infectious Diseases, the First Hospital, Beijing University, Beijing 100034,China. |
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| Abstract: | Objective To study the quantity of anti R7V in individuals infected with HIV and AIDS patients and its relation with the progression of disease. Methods ELISA and precipitation and other methods were used to investigate the quantity of anti R7V in asymptomatic long term survivors and AIDS patients. Results Positive rate and quantity of anti R7V were higher in the HIV actiue ones and AIDS. It showed that the quantity and positive rate of anti R7V were rather high in dissolving test. Conclusion It is strong suggestion for anti R7V to obstruct the replication of virus by interfering the connection between HIV with CCR5 or CXCR4 and so it impossible HIV entering to CD4 +T cells. |
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| Keywords: | HIV Peptides CCR |
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