| 慢性疼痛的JNK信号转导通路机制的研究进展 |
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| 引用本文： | 邱宇洁,梁宜,方剑乔,房军帆,杜俊英,刘晋. 慢性疼痛的JNK信号转导通路机制的研究进展[J]. 浙江中医药大学学报, 2011, 0(5): 793-796 |
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| 作者姓名： | 邱宇洁 梁宜 方剑乔 房军帆 杜俊英 刘晋 |
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| 作者单位： | 浙江中医药大学第三临床医学院 杭州 310053 |
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| 基金项目： | 国家自然科学基金，浙江省研究生创新科研项目，浙江省自然科学基金，浙江省中医药科技计划项目 |
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| 摘 要： | JNK信号转导通路是丝裂原活化蛋白激酶(MAPK)重要的信号转导通路之一,在慢性疼痛的产生和维持中发挥着重要的作用。外周神经受到刺激后,JNK通过磷酸化的形式被激活,然后将胞质内信号转移到胞核中,产生痛觉过敏或痛觉异常。
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| 关 键 词： | 慢性疼痛 信号通路 JNK TAK1 MCP-1 |
Recent Research Progress on the Mechanism of Chronic Pain via JNK Signal Transduction Pathway |
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| Affiliation: | Qiu Yujie,Liang Yi,Fang Jianqiao,et al Third Clinical Medical College of Zhejiang Chinese Medical University,Hangzhou(310053) |
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| Abstract: | The c-Jun N-terminal kinase is a stress activated member of MAP kinase family for intracellular signal transduction and plays critical role in the development and maintenance of chronic pain.Once peripheral nerve is damaged,JNK is activated by phosphorylation then transducts cell signal from cytoplasm to nucleus,which are associated with hyperalgesia and allodynia. |
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| Keywords: | chronic pain signal transduction pathway JNK TAK1 MCP-1 |
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