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| 血府逐瘀汤对野百合碱诱导肺血管重构大鼠ET-1、NO的干预作用 | |
| 引用本文： | 何飞,徐俭朴,吴晓晖,蔡宛如,王辉,刘莎,洪辉华.血府逐瘀汤对野百合碱诱导肺血管重构大鼠ET-1、NO的干预作用[J].浙江中西医结合杂志,2011,21(11):765-767,F0004. |
| 作者姓名： | 何飞 徐俭朴 吴晓晖 蔡宛如 王辉 刘莎 洪辉华 |
| 作者单位： | 1. 浙江省中西医结合医院,杭州,310003 2. 浙江中医药大学,杭州,310053 3. 浙江省中医院 |
| 基金项目： | 浙江省中医药科技计划项目 |
| 摘 要： | 目的：观察血府逐瘀汤（XFZYT）对野百合碱（MCT）诱导肺血管重构大鼠ET-1、NO干预作用,探讨其作用机制。方法：雄性SD大鼠54只,随机分成正常对照组、模型组、血府逐瘀汤预防组、血府逐瘀汤治疗组、对照Ⅰ组和对照Ⅱ组,每组9只。采用一次性腹腔注射MCT（60mg/kg）复制肺血管重构模型,血府逐瘀汤预防组、对照Ⅰ组造模第2天起给药,血府逐瘀汤治疗组、对照Ⅱ组造模第15天起给药。至实验第28天采集组织标本,观察各组大鼠肺血管病理形态学及测定血ET-1、NO含量变化。结果：与正常对照组比较,模型组大鼠肺小动脉管壁变厚、管腔变小,血浆ET-1增多,血清NO减少（P〈0.01）;与模型组比较,各药物组血浆ET-1含量降低,血清NO含量升高（除外血府逐瘀汤治疗组）,肺小动脉管壁有不同程度变薄、管腔变大（P〈0.01~0.05）。结论：血府逐瘀汤能有效减轻大鼠肺血管重构,其机制可能与通过调节ET-1和NO代谢有关。 |
| 关 键 词： | 大鼠 肺血管重构 血管内皮功能 血府逐瘀汤 |
Effect of Xuefuzhuyutang on Endothelin-1 and NO in Rats with Pulmonary Vascular Remodeling Induced by Monocrotaline |
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| HE Fei,XU Jianpu,WU Xiaohui,et al..Effect of Xuefuzhuyutang on Endothelin-1 and NO in Rats with Pulmonary Vascular Remodeling Induced by Monocrotaline[J].Zhejiang Journal of Integrated Traditional Chinese and Western Medicine,2011,21(11):765-767,F0004. | |
| Authors: | HE Fei XU Jianpu WU Xiaohui |
| Institution: | HE Fei,XU Jianpu,WU Xiaohui,et al.Zhejiang Province Hospital of the Integration of Traditional Chinese and Western Medicine,Hangzhou(310003),China |
| Abstract: | Objective: To observe the effect of Xuefuzhuyutang(XFZYT) on the levels of endothelin-1(ET-1)and NO in the rats with remodeling pulmonary arteried induced by monocrotaline(MCT).Methods: A total of 54 SD rats were randomized into a normal control group,model group,XFZYT prevention group,XFZYT treatment group,control I group,and control II group,9 in each.MCT of 60 mg/kg was applied one off to establish the model of pulmonary vascular remodeling.The XFZYT prevention group and I group started intervention from... |
| Keywords: | rats pulmonary vascular remodeling endothelial function XFZYT |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |