| 寻常性银屑病患者外周血Th17／Treg平衡偏移的研究 |
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| 引用本文： | 陈晋广,赖维,姜昱.寻常性银屑病患者外周血Th17／Treg平衡偏移的研究[J].中国中西医结合皮肤性病学杂志,2013(6):353-355. |
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| 作者姓名： | 陈晋广 赖维 姜昱 |
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| 作者单位： | [1]广东省中山市人民医院,中山528403 [2]浙江省台州市立医院,台州318000 [3]中山大学附属第三医院,广州510630 |
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| 基金项目： | 中国博士后科学基金（2012M521655）,浙江省卫生厅（2013KYA231）,中山市卫生局（2013J038） |
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| 摘 要： | 目的通过检测寻常性银屑病患者血清中卟17、Treg细胞的水平，探讨其在银屑病发病机制中的作用。方法选择46例寻常性银屑病患者和20例健康人为研究对象，采用流式细胞技术检测外周血Thl7细胞和CD4＋CD25＊Treg细胞亚群。结果银屑病患者Thl7表达水平明显高于正常对照组，而Treg与正常对照组比较差异无统计学意义；患者Thl7／Treg表达水平与患者PASI评分呈正相关。结论银屑病患者外周血中Thl7／Treg细胞表达失衡可能拳与了其发病的过程。
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| 关 键 词： | 银屑病 辅助性T细胞17 调节性T细胞 |
Study on the Shift of Th17/Treg in Patients with Psoriasis Vulgaris |
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| CHEN Jinguang,＇,LAI Wei,JIANG Yu.Study on the Shift of Th17/Treg in Patients with Psoriasis Vulgaris[J].Chinese J of Dermatovenerology Integr Tradit and West Med,2013(6):353-355. |
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| Authors: | CHEN Jinguang ＇ LAI Wei JIANG Yu |
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| Institution: | 1. People ＂s Hospital of Zhongshan City, Zhongshan 528403, China; 2. Taizhou Municipal Hospital, Taizhou 318000, China,. 3. The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China |
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| Abstract: | Objective To investigate the alteration and significance of Thl 7,rl＇reg cell in patients with psoriasis vulgaris. Methods 46 patients were observed and 20 heahhy people were enrolled as controls. The frequencies of Treg, Th17 in peripheral blood were detected by flow cytometric analysis. Results The frequencies of Th17 in peripheral blood were significantly increased in psoriasis, compared with controls; and Thl7~reg were positive correlated with PASI. There was no statistical difference between the two groups in Treg. Conclusion Th17/Treg responsive model of psoriasis is different from that of controls, the alteration of Th 17/Freg might play a roles in the pathogenesis of psoriasis. |
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| Keywords: | Psoriasis T helper 17 Cells Regulatory T cell |
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