| L-选择素在体外循环中的表达及其拮抗剂的肺保护作用 |
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| 引用本文： | 薛金熔,刘迎龙,王强,温福兴,关彬.L-选择素在体外循环中的表达及其拮抗剂的肺保护作用[J].中华胸心血管外科杂志,2004,20(3):164-166. |
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| 作者姓名： | 薛金熔 刘迎龙 王强 温福兴 关彬 |
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| 作者单位： | 1. 100037,北京,中国协和医科大学,中国医学科学院,心血管病研究所,阜外心血管病医院先心病研究室
2. 100037,北京,中国协和医科大学,中国医学科学院,心血管病研究所,阜外心血管病医院麻醉研究室 |
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| 基金项目： | 国家“十五”科技攻关计划项目资助(2 0 0 2BA70 9B0 9) |
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| 摘 要： | 目的研究体外循环术后L-选择素的表达以及应用其拮抗剂进行肺灌注，探讨肺损伤发生的机制和阻断L-选择素表达所起的肺保护作用。方法采用大鼠体外循环及术中肺灌注模型，观察手术前、后及应用拮抗剂后L-选择素的表达，组织超氧化物歧化酶(SOD)、丙二醛(MDA)、髓过氧化物酶(MPO)含量变化，氧指数(PaO2／FiO2)及组织学改变。结果体外循环术后L-选择素的表达增加，应用其拮抗剂进行肺灌注后其表达明显降低，肺损伤相应减轻。结论L-选择素参与了体外循环中肺损伤的发生，阻断其表达可以减轻体外循环肺损伤，改善术后肺功能。
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| 关 键 词： | L-选择素 体外循环 L-选择素拮抗剂 肺保护 肺损伤 |
Expression of L-selectin in rat models undergoing cardiopulmonary bypass and the pulmonary protective effect of its antagonist |
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| Abstract: | Objective: To study the expression of L selectin and its possible role in pulmonary injury in rat models undergoing cardiopulmonary bypass (CPB) and to investigate the protecive effect of fucoidin during the procedure. Methods: Models of CPB and pulmonary perfusion in rats were used to investigate the expression of L selectin pre and post operation. Its expression in antagonist group was also studied. Other indexes, including the concentration of SOD, MDA and MPO in rat lung tissues as well as PaO 2/FiO 2 and histological changes, were studied to illustrate the possible mechanism of L selectin in lung reperfusion injury. Results: The expression of L selectin increased after creating CPB but decreased after pulmonary infusion with fucoidin during the procedure, and lung injury relieved as well. Conclusion: L selectin might lead to lung injury during CPB, blocking its expression may relieve lung injury and enhance the recovery of lung function. |
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| Keywords: | L-selectin Reperfusion injury Lung Fucoidin |
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