| 食物对氧氟沙星生物利用度的影响 |
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| 引用本文： | 万新祥,张立,张璘 ,骆军,田四琦.食物对氧氟沙星生物利用度的影响[J].中国新药与临床杂志,1995(3). |
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| 作者姓名： | 万新祥 张立 张璘 骆军 田四琦 |
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| 作者单位： | 广州医学高等专科学校 |
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| 摘 要： | 在空腹和进食条件下分别交叉给９名健康志愿者（男性，平均年龄２５±ｓ７ａ）口服氧氟沙星片２×１００ｍｇ，采用ＨＰＬＣ法测定经时过程血药和尿药浓度，并计算其药物动力学参数。结果表明：进食对氧氟沙星片剂生物利用度无明显影响，但可延缓该药的吸收。
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| 关 键 词： | 氧氟沙星，食品，生物学效用，药物动力学 |
Influence of food on bioavailability of ofloxacin |
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| WAN Xin-Xiang,ZHANG Li,ZHANG Lin,LUO Jun,TIAN Si-Qi.Influence of food on bioavailability of ofloxacin[J].Chinese Journal of New Drugs and Clinical Remedies,1995(3). |
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| Authors: | WAN Xin-Xiang ZHANG Li ZHANG Lin LUO Jun TIAN Si-Qi |
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| Abstract: | The ofloxacin tablets 2× 100mg were administered to 9 healthy volunteers under the conditions of fasting and after meal in a cross-over time.The HPLC method was used to determine ofloxacin concentrations in serum and urine.The results showed that food had little influence on the bioavailability, but delayed the absorption rate of ofloxacin.The Parameters Tmax in fasting and postprandial were 1.1±0.3 and 2.2± 0.3h(P<0.01).Cmax were 1.9± 0.4 and 1.31± 0.19 mg/ L(P<0.01),AUC0-24 were13± 4 and 11.7±2.4 mg·h/ L(P>0.05) and the amounts of ofloxacin excreted in urine within 24 h were 69%±6%and 67%±4%(P>0.05)respectively. |
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| Keywords: | ofloxacin food biological availability pharmacokinetics |
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