健康综合干预对糖耐量减低患者IL-10及hs-CRP的影响

目的：探讨糖耐量减低（IGT）患者血清炎症因子白介素-10（IL-10）、高敏c-反应蛋白（hs-CRP）的水平变化及健康综合干预对糖耐量减低患者血清炎症因子的影响。方法：检测正常对照组、IGT非干预组、IGT干预组共90例的空腹血清hs-CRP、IL-10浓度,并对它们进行方差分析,同时检测血糖、血脂、肝功能及胰岛素水平,并采用稳态模型法计算IR I。结果：空腹血清hs-CRP浓度：在IGT非干预组（17 564±16 576μg/L）、IGT干预组（9 378±6 296μg/L）和正常对照组（4 263±1 861μg/L）,3组之间差异有统计学意义（P〈0.01）,IGT非干预组显著高于IGT干预组和正常对照组（P〈0.05）。IL-10浓度：3组分别为IGT非干预组（14.2±6.7 ng/L）、IGT干预组（21.9±10.1 ng/L）和正常对照组（28.7±11.8 ng/L）,3组之间差异有统计学意义（P〈0.01）,IGT非干预组显著低于IGT干预组（P〈0.05）。结论：IGT患者血清前炎症因子、hs-CRP水平明显升高,IL-10水平明显降低,IGT患者处于慢性低度炎症状态;健康综合干预后、hs-CRP浓度显著下降,IL-10浓度明显升高,健康综合干预可显著改善IGT患者的慢性低度炎症状态。

Effects of Health Synthetic Intervention of Inflammatory Markers in Metabolic Syndrome Patients

Objective：To investigate the serum interleukin-10（IL-10）﹑hs-CRP level change in patients with metabolic syndrome（IGT）.Methods：Fasting blood serum IL-10,hs-CRP concentrations were measured from 90 cases,including metabolic syndrome patients without intervention,metabolic syndrome patients with health intervention and control subjects;and fasting insulin（FINS） in all cases for calculating insulin resistance index（homeostasis model assessment,HOMA-IR）,analyze the relationship between them.Results：Fasting blood serum hs-CRP concentration in IGT subjects without intervention was higher than that in control subjects and IGT subjects with intervention（P〈0.01）;IGT subjects without intervention was higher than that in IGT subjects with intervention（P〈0.05）.Fasting blood serum IL-10 concentration in IGT subjects without intervention was lower than that in Control subjects and IGT subjects with intervention（P〈0.01）;IGT subjects without intervention was lower than that in IGT subjects with intervention too（P〈0.05）.Conclusions：Fasting blood serum hs-CRP levels increased and IL-10 levels decreased in patients with metabolic syndrome（IGT）,IGT subjects were in chronic low inflammation.Chronic low inflammation can be improved in metabolic syndrome patients after taking health synthetic intensive intervention.