| 蛇毒抗栓酶对氧自由基致血小板变化的影响 |
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| 引用本文： | 陈丽英,张抒扬.蛇毒抗栓酶对氧自由基致血小板变化的影响[J].基础医学与临床,1994,14(2):34-37. |
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| 作者姓名： | 陈丽英 张抒扬 |
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| 作者单位： | 中国医学科学院基础医学研究所病理生理研究室，协和医院内科心组 |
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| 摘 要： | 次黄嘌呤／黄嘌呤氧化酶体系产生的氧自由基在体外能明显增加血中板膜微粘度，脂质过氧化代射产物丙二醛含量，血小板胞内游离钙浓度和血小板５－羟色胺的释放量。０．０３ｕ／ｍｌ的蛇毒抗栓酶明显抑制前二种效应，但促进血小板释放５－羟色胺，增加血小板胞内游离钙浓度，结果表明蛇毒抗栓酶对血小板膜有保护作用。
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| 关 键 词： | 氧 自由基 血小板 蛇毒抗栓酶 |
Effect of Snake Venom Antithrombus Enzyme on The Change of Platelet Induced by Oxyradicals |
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| Chen Liying Xu Shuhuai Jin Shumin Zhang Shuyang Jin Lan.Effect of Snake Venom Antithrombus Enzyme on The Change of Platelet Induced by Oxyradicals[J].Basic Medical Sciences and Clinics,1994,14(2):34-37. |
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| Authors: | Chen Liying Xu Shuhuai Jin Shumin Zhang Shuyang Jin Lan |
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| Abstract: | he experiments were performed with rabbit platelet suspension(PSS)to studythe effect of snake venom antithrombus enzyme(SVATE)on platelets in vitro.In thispaper,the production of free radicals derived from hypoxanthine(HX) /xanthineoxidase(XO) ,platelet malondialdehyde (MDA) ,platelet membrane microvisco-sity,5-HT released from platelet and plateletCa2+]i were respectively measur-ed.The experiments were divided into 4 groups:1.PSS(control);2.PSS + HX/XO; 3.PSS + SVATE;4.PSS + SVATE + HX/XO.The results showed that pla-telet membrane microviscosity,the production of MDA and 5-HT and plateletCa2+]i were significantly increased by oxyradicals.The intervention ofSVATE can significantly inhibit the two former effecls of oxyradicals and incre-ase 5-HT release of platelet and plateletCa2+]i.The results indicate thatSVATE has a protective effect on platelet membrane. |
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| Keywords: | oxyradicals platelet snake venom antithrombus enzyme(SVATE)Division of Cardiology Internal Medicine PUMC Hospital |
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