Effects of thromboxane and prostacyclin imbalance on hemodynamics and hemorrheology in severely burn patients

Fifty-seven bum patients were dosdy observed for 28 d postburn.In general,plasma levelof thromboxane B_2(TXB_2),6-keto-PGF_(lx) and TXB_2/6-keto-PGF_(lx) ratio all rose up abruptly tothe peak in the first half day after burns and then declined gradually.However the patterns of theirchanges were different:6-keto-PGF_(lx) returned to the control level in the 2nd day postburn,remained in a higher level than the control even in the 5th day postburn,and the increase ofTXB_2/6-keto-PGF_(lα) ratio was especially pronounced in the first 3 d postbum.It was also shownthat the changes of hemodynamics and hemorrheology occurred simultaneously with the imbalanceof thromboxane and prcstacyclin in the early postburn stage.The extent of the imbalance accordedwith the severity of hemodynamical and hemorrheological changes and was closely correlated withthe changes with the stroke volume,cardiac output,systemic vascular resistance,circulatory plateletaggregate ratio,platelet count and blood vinery.These findings suggest that the imbalance be-tween thromboxane and prostacyclin plays an important role in the changes of hemodynamics andhemorrheology in severe burn cases.

Effects of thromboxane and prostacyclin imbalance on hemodynamics and hemorrheology in severely burn patients