| 孕酮对大鼠视网膜缺血-再灌注损伤的保护作用 |
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| 引用本文： | 卢娜,李超,程远,杜爱林.孕酮对大鼠视网膜缺血-再灌注损伤的保护作用[J].南方医科大学学报,2008,28(11):2026-2029. |
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| 作者姓名： | 卢娜 李超 程远 杜爱林 |
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| 作者单位： | 1. 新乡医学院生理学与神经生物学教研室
2. 新乡医学院第三附属医院眼科,河南,新乡,453003 |
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| 摘 要： | 目的 探讨孕酬对SD大鼠实验性高眼压视网膜缺血一再灌注损伤后的保护作用及机制,并评估其在视网膜缺血性疾病中的应用价值,为临床应用提供实验依据.方法 采用跟内灌注法,前房灌注生理盐水制成视网膜缺血-再灌注模型.32只SD大鼠随机分为对照组、正常组、二甲基亚砜溶剂对照组、孕酮治疗组.孕酬治疗组于缺血前30 min与再灌注2 h后接4 mg/kg腹腔内注射孕酮溶液;二甲基亚砜溶剂对照组于缺血前30 min和缺血后2 h分别腹腔注射相当体积的二甲基亚砜.各组分别于再灌注6h后空气栓塞法处死动物.用硫代巴比妥法测定丙二醛(MDA)含量,黄嘌呤氧化酶法测定超氧化物歧化酶(SOD)活性,并观察视网膜组织形态学与超微结构的改变.结果 (1)再灌注6h后.对照组视网膜MDA含量较阴性对照组显著增高(P
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| 关 键 词： | 孕酮 缺血再灌注损伤 视网膜 丙二醛 超氧化物歧化酶 |
Protective effects of progesterone against high intraocular pressure-induced retinal ischemia-reperfusion in rats |
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| LU Na,LI Chao,CHENG Yuan,DU Ai-lin.Protective effects of progesterone against high intraocular pressure-induced retinal ischemia-reperfusion in rats[J].Journal of Southern Medical University,2008,28(11):2026-2029. |
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| Authors: | LU Na LI Chao CHENG Yuan DU Ai-lin |
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| Institution: | LU Na1,LI Chao2,CHENG Yuan1,DU Ai-lin1 Department of Physiology , Neurobiology1,Department of Ophthalmology,Third Affiliated Hospital2,Xinxiang Medical College,Xinxiang 453003,China |
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| Abstract: | Objective To investigate the protective effect of progesterone against high intraocular pressure-induced ischemia-reperfusion (IR) injury.Methods Twenty-four SD rats were randomly divided into normal control,IR model,dimethyl sulfoxide (DMSO) solvent treatment group,and progesterone treatment group.In the latter 3 groups,retinal IR injury was induced by intraocular injection of saline.In the progesterone group,intraperitoneal injections of 4 mg/kg progesterone were administered 30 min before and 2 h after i... |
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| Keywords: | progesterone ischemia-reperfusion retina malondialdehyde superoxide dismutase |
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