与肾小球滤过率相关的临床因素探讨

目的：探讨肾小球滤过率（GFR）与多种临床因素的相关关系。方法：用^99mTc-DTPA清除率测定46例肾功能正常组和52例肾功能不全组患者的GFR，同时采血测血清肌酐（SCr）、尿素氮（BUN）、尿酸、钾、钠、钙、血红蛋白，并测心率、尿质量比、24h尿蛋白定量、平均动态压、体重指数、体表面积，记录测试者年龄，测定GFR所用同位素剂量。将各组及不同原发病的GFR分别与同组的上述各临床因素进行简单相关分析，对与GFR有显著相关关系的上述临床因素再与GFR进行多元相关分析。结果：在肾功能正常、肾功能不全及不同原发病者中，除例数较少的病种外，其GFR始终与SCr呈显著负相关，而与其他临床因素的相关关系则不相同。结论：在多种原发病引起的肾功能不全及肾功能正常者中，SCr是反映GFR的理想指标。

Study of the clinical factors associated with glomerular filtration rate

Objective:To investigate the relationship between glomerular filtration rate(GFR) and possible involved clinical factors and to offer an basis for building measurement GFR by the calculation method. Methods: GFR from 46 cases of normal renal function group and 52 cases of renal insufficient group were determined by using clearance of 99m TcDTPA,serum creatinine(SCr),urea nitrogen,uric, potassium , sodium, calcium and hemoglobin were determined.Simultaneously,heart rate,urine specific gravity, 24 hours urine protein quantum,average artery pressure,weight index and body surface area were determined.Age, isotope dose for determining GFR were recorded.The simple correlation analysis between GFR in every group and the difference primitive diseases and clinical factors mentioned above were performed and the multiple correlation analysis between every clinical factors mentioned above that had significantly correlation between GFR and GFR were performed as well.Results:GFR in normal renal function group,insufficient group and the difference primitive diseases had significantly negative correlation with SCr,while the correlations between GFR and other clinical factors were different.Conclusion:SCr is the ideal index for GFR for renal insufficient patients due to different primitive diseases and patients with normal renal function.