吡格列酮和罗格列酮治疗老年2型糖尿病的疗效对比(英文)

目的 探讨吡格列酮和罗格列酮对2型糖尿病患者血糖、血脂水平的影响.方法 将我院内分泌科门诊及病房收治的符合1997年WHO诊断标准的2型糖尿病患者64例.予以饮食控制,运动治疗,且同时口服降糖药物固定在1mo以上,空腹血糖仍≥7 mmol·L-1的患者,随机分为吡格列酮组和罗格列酮组,分别加用吡格列酮或罗格列酮12 wk.结果 ①吡格列酮组和罗格列酮组的空腹血糖、餐后2 h血糖、糖化血红蛋白、胰岛素抵抗指数均较治疗前明显降低(P＜0.05),两者之间降低的程度没有显著性差异.②毗格列酮组血三酰甘油和总胆固醇水平较治疗前明显降低(P＜0.05),但罗格列酮组无明显变化(P＞0.05).③2组的高密度脂蛋白水平均比治疗前明显升高(P＜0.05和P＜0.01),但吡格列酮组升高的幅度大于罗格列酮组.结论 吡格列酮和罗格列酮治疗后均能有效控制血糖,但吡格列酮能更明显地改善血脂.

Comparison of clinical effects between rosiglitazone and pioglitazone in the treatment of type 2 diabetes of eldly patients

AIM To compare the clinical effects of rosiglitatine with pioglitazone in the treatment of type 2 diabetic patients.METHODS Sixty-four patients who had been treated with food control,exercise and fixed oral anti-dia-betic drugs for one month,but their fasting plasma glucose level was still over 7 rranol·L-1.They were randomized divided into two groups.One was added with rosiglitazone,the other was added with pioglitazone.All of them were treated for 12 weeks.RESULTS After treatment for 12 weeks,①patient's fasting plasma glucose,postprandial plasma glucose,HbA1c and insulin resistance index were significant decreased in both groups;②triglyceride and total cholesterol were decreased in pioglitazone group(P＜0.05),but those in rosiglitagone group were no significant reduction(P＞0.05);③high density lipoprotein-cholesterol was elevated in both groups(P＜0.05).CONCLUSION Rosiglitazone or pioglita zone can be used to control blood glucose,but pioglitazone shows more efficiency on triglyceride control.