Electrical stimulation reveals relatively ineffective sural nerve projections to dorsal horn neurons in the cat |
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| Authors: | Lilian M. Pubols Mark E. Foglesong Christiane Vahle-Hinz |
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| Affiliation: | 1. Department of Microbiology, Institute of Medical Sciences & SUM Hospital, Siksha O Anusandhana University, Bhubaneswar, 751003 Odisha, India;2. Department of Biochemistry, Institute of Medical Sciences & SUM Hospital, Siksha O Anusandhana University, Bhubaneswar, 751003 Odisha, India;3. Department of Urology, Institute of Medical Sciences & SUM Hospital, Siksha O Anusandhana University, Bhubaneswar, 751003 Odisha, India;1. Division of Experimental Medicine, Department of Medicine, McGill University, Montreal, Quebec, Canada;2. The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, Quebec, Canada;3. Department of Human Genetics, McGill University, Montréal, Québec, Canada;4. Alberta Children''s Hospital, Medical Genetics, Calgary, Alberta, Canada;5. Department of Pharmacology & Therapeutics and Centre de Recherche en Biologie Structurale - FRQS, McGill University, Montréal, Canada;6. Faculty of Medicine, McGill University, Montreal, QC, Canada;7. Department of Neurology, Université de Sherbrooke, Sherbrooke, Québec, Canada;8. Divisions of Neurology and Clinical and Metabolic Genetics, Department of Paediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada;9. Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada;10. Children''s Hospital of Eastern Ontario Research Institute, University of Ottawa, Ottawa, Ontario, Canada;11. Department of Medicine, Faculty of Medicine, Université Laval, Québec City, Quebec, Canada;12. Neuroscience Axis, CHU de Québec-Université Laval, Québec City, Québec, Canada;13. Departments of Medicine (Neurology) and Medical Genetics, University of Alberta, Edmonton, Alberta, Canada;14. Department of Neurology and Neurosurgery, McGill University, Montréal, Québec, Canada |
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| Abstract: | Electrical stimulation of the sural nerve (SN) revealed input from sural nerve afferents to L6 and L7 dorsal horn neurons that were not apparent using natural mechanical stimuli, especially in cells with variable latency responses to SN stimulation. Nearly all (31/32) cells that had reliable, fixed latency responses to SN stimulation also had an excitatory receptive field (RF) in the region of skin innervated by the sural nerve (SN region). About one-third (20/57) of the cells with variable latency responses to SN stimulation, however, had an RF outside the SN region. Most (130/146) cells with no response to SN stimulation had RFs outside the SN region. There were no obvious differences between variable latency cells with RFs in the SN region vs those with RFs outside it in latency of response to SN stimulation, recording depth, RF sizes or modality properties. In a subsample of 31 postsynaptic dorsal column neurons all cells responding to SN stimulation also had an RF in the SN region. Strengthening of relatively ineffective projections from the sural nerve by lesions might be expected to lead to an increase in the proportion of cells responding with impulses to natural stimulation of the skin innervated by the sural nerve, and, hence, to an increase in average RF size. |
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| Keywords: | dorsal horn ineffective projection sural nerve |
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